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Cardiac extracellular matrix : fundamental science to clinical applications

Author: Eric G Schmuck; Peiman Hematti; Amish N Raval
Publisher: Cham, Switzerland : Springer, [2018] ©2018
Series: Advances in experimental medicine and biology, v. 1098.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM's role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Cardiac extracellular matrix.
Singapore : Springer, [2018]
(OCoLC)1042404252
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Eric G Schmuck; Peiman Hematti; Amish N Raval
ISBN: 9783319974217 3319974211 9783319974224 331997422X
OCLC Number: 1054887842
Description: 1 online resource (xii, 246 pages) : illustrations (some color)
Contents: Biomechanical properties and mechanobiology of cardiac ECM / Michael Nguyen-Truong, Zhijie Wang --
Imaging the cardiac extracellular matrix / Michael A. Pinkert, Rebecca A. Hortensius, Brenda M. Ogle, Kevin W. Eliceiri --
Animal models and cardiac extracellular matrix research / Timothy A. Hacker --
Applications of cardiac extracellular matrix in tissue engineering and regenerative medicine / Mark C. Daley, Spencer L. Fenn, Lauren D. Black III --
Whole cardiac tissue bioscaffolds / Karis R. Tang-Quan, Nicole A. Mehta, Luiz C. Sampaio, Doris A. Taylor --
Natural sources of extracellular matrix for cardiac repair / Keith L. Spinali, Eric G. Schmuck --
Cardiac extracellular matrix modification as a therapeutic approach / Mikayla L. Hall, Brenda M. Ogle --
Extracellular matrix for myocardial repair / Jenna L. Dziki, Stephen F. Badylak --
Role of extracellular matrix in cardiac cellular therapies / Peiman Hematti --
Regulation of regenerative medicine products / Adrian P. Gee --
Clinical trial design for investigational cardio-regenerative therapy / Amish N. Raval --
Regenerative medicine venturing at the university-industry boundary: implications for institutions, entrepreneurs, and industry / Adam J. Bock, David Johnson.
Series Title: Advances in experimental medicine and biology, v. 1098.
Responsibility: edited by Eric G. Schmuck, Peiman Hematti, Amish N. Raval.

Abstract:

Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research,  Read more...

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Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities.<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"Biomechanical properties and mechanobiology of cardiac ECM \/ Michael Nguyen-Truong, Zhijie Wang -- Imaging the cardiac extracellular matrix \/ Michael A. Pinkert, Rebecca A. Hortensius, Brenda M. Ogle, Kevin W. Eliceiri -- Animal models and cardiac extracellular matrix research \/ Timothy A. 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