Cardioprotective effects of exercise training : the importance of nitric oxide (Book, 2008) [WorldCat.org]
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Cardioprotective effects of exercise training : the importance of nitric oxide

Author: M C de Waard
Publisher: [S.l.] : [The Author] ; Rotterdam : Erasmus University [Host], 2008.
Dissertation: Thesis Erasmus University Rotterdam.
Edition/Format:   Thesis/dissertation : Document : Thesis/dissertation : eBook   Computer File : EnglishView all editions and formats
Summary:
Left ventricular remodeling after myocardial infarction is a compensatory mechanism, which serves to restore left ventricular pump function to normal levels. Despite the apparent appropriateness of the process, left ventricular remodeling after myocardial infarction is an independent risk factor for the development of angina pectoris and heart failure. In contrast, physiological left ventricular remodeling produced  Read more...
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Details

Genre/Form: Proefschriften (vorm)
Additional Physical Format: Cardioprotective effects of exercise training
(NL-LeOCL)314198415
Material Type: Document, Thesis/dissertation, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: M C de Waard
ISBN: 9789085594048 9085594049
OCLC Number: 1239350149
Notes: ook verschenen in gedrukte versie.
Description: 1 online resource (?)
Responsibility: Monique Chantal de Waard.

Abstract:

Left ventricular remodeling after myocardial infarction is a compensatory mechanism, which serves to restore left ventricular pump function to normal levels. Despite the apparent appropriateness of the process, left ventricular remodeling after myocardial infarction is an independent risk factor for the development of angina pectoris and heart failure. In contrast, physiological left ventricular remodeling produced by regular exercise training is associated with a decreased risk for heart failure. This PhD-project focuses on the physiological, cellular and molecular basis for the differences in myocardial remodeling between exercise-induced and pathological left ventricular remodeling. In addition, we investigate how regular exercise training favorably influences the myocardial abnormalities associated with pathological left ventricular remodeling, in particular, the role of an increased nitric oxide production in the beneficial effects of exercise training. For this purpose, studies are performed in wild-type mice but also eNOS transgenic or knock-out mice. Specifically we test the hypothesis that eNOS overexpression mimics exercise training and that eNOS knock-out abrogates the beneficial effects of exercise training in mice with a myocardial infarction.

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