Case studies in modern drug discovery and development (Book, 2012) []
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Case studies in modern drug discovery and development

Author: Xianhai Huang; Robert G Aslanian
Publisher: Hoboken, New Jersey : Wiley, ©2012.
Edition/Format:   Print book : EnglishView all editions and formats

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Genre/Form: Case studies
Document Type: Book
All Authors / Contributors: Xianhai Huang; Robert G Aslanian
ISBN: 9780470601815 0470601817
OCLC Number: 951387285
Description: XVIII, 451 str. : ilustr. ; 26 cm.
Contents: Introduction: drug discovery in difficult times / Malcom MacCoss --
Discovery and development of the DPP-4 inhibitor JANUVIA? (Sitagliptin) / Emma R. Parmee [and others] --
Olmesartan medoxiomil, an angiotensin II receptor blocker / Hiroaki Yanagisawa, Hiroyuki Koike, and Shinichiro Miura --
Discovery of heterocyclic phosphonic acids as novel AMP mimics that are potent and selective fructose-1,6-bisphosphatase inhibitors and elicit potent glucose-lowering effects in diabetic animals and human / Qun Dang, and Mark D. Erion --
Setting the paradigm of targeted drugs for the treatment of cancer : Imatinib and Nilotinib therapies for chronic myelogenous leukaemia / Paul W. Manley and Jürg Zimmermann --
Amrubicin, a completely synthetic 9-aminoanthracycline, for extensive-disease small-cell lung cancer / Mitsuharu Hanada --
The discovery of dual IGF-1R and IR inhibitor FQIT for the treatment of cancer / Meizhong Jin, Elizabeth Buck, and Mark J. Mulvihill --
Discovery and development of Montelukast (Singulair?) / Robert N. Young --
Discovery and development of Maraviroc, a CCR5 antagonist for the treatment of HIV Infection / Patrick Dorr, Blanda Stammen, Elna van der Ryst --
Discovery of antimalarial drug Artemisinin and beyond / Ao Zhang, Weiwei Mao, Yu Zhang --
Discovery and process development of MK-4965, a potent non-nucleoside reverse transcriptase inhibitor / Yong-Li Zhong, Thomas J. Tucker, and Jingjun Yin --
Discovery of Boceprevir and Narlaprevir : the first and second generation of HCV NS3 protease inhibitors / Kevin X. Chen, F. George Njoroge --
The discovery of Samsca (Tolvaptan) : the first oral nonpeptide vasopressin receptor antagonist / Kazumi Kondo, Yoshitaka Yamamura --
SILODOSIN (Urief?, Rapaflo?, Thrupas?, Urorec?, SilodixTM) : a selective à1A adrenoceptor antagonist for the treatment of benign prostatic hyperplasia / Masaki Yoshida [and others] --
Raloxifene : a selective estrogen receptor modulator (SERM) / Jeffrey A. Dodge and Henry U. Bryant.
Responsibility: edited by Xianhai Huang, Robert G. Aslanian.


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