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Cell therapy : current status and future directions

Author: Dwaine F Emerich; Gorka Orive
Publisher: New York, NY : Humana Press, 2017.
Series: Molecular and translational medicine.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This volume provides a comprehensive, state-of-the art review of the field of cell therapy. The volume begins with an overview of the breadth of the field and then turns to overviews of imaging technologies that can aid in both safety and efficacy evaluations. The book then turns to numerous contributions detailing the rapidly growing field of stem cell therapies. These sections cover our understanding of the  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
(OCoLC)981165062
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Dwaine F Emerich; Gorka Orive
ISBN: 9783319571539 3319571532
OCLC Number: 1002190847
Description: 1 online resource
Contents: Encapsulating Islets: Biomass Considerations Islet Encapsulation Failure Modes;Subacute Processing Stress; Acute Implant Failure; Chronic Failure of Cell Encapsulation Systems; Immune Rejection; Hypoxia; Strategies for Addressing Hypoxia; Refillable Gas Supply; Artificial Oxygen Carriers; Vascularization; Strategies for Mitigating Chronic Fibrosis; Coatings and Covalent Modifications; Stem Cell-Derived B-Cells as an Alternative to Isolated Cadaveric Islets; Generation of Glucoresponsive Stem Cell-Derived B-Cells; Clinical Translation of Stem Cell-Derived B-Cells. The Future of B-Cell TherapyReferences; 3: Stem Cell Therapy for Neurovascular and Traumatic Brain Diseases; Introduction; Acute Pathology of Stroke and TBI; Chronic Pathology of Stroke and TBI; Stem Cell Therapy for Neurovascular Disorders; Stem Cell Transplantation in Stroke; Stem Cell Transplantation in TBI; Mechanisms of Stem Cell Therapy; The Promise of Combination Therapies with Stem Cells; The Spleen as a Novel Target for Stem Cells; Challenges in Stem Cell Therapy; Potential Adverse Effects of Stem Cell Therapy; Cell-Free Materials and Exosomes in Neurovascular Therapy. Dedication; Preface: A Brief Introduction to the Span of Cell Therapy; Contents; Contributors; 1: Molecular Considerations in Cell Transplant Imaging; Introduction; The Need for Molecular Imaging: Limitations of Cell-Based Therapies;Recent Advances in Molecular Imaging;Bright-Field and Fluorescent Optical Imaging; PET Imaging; Bioluminescence Imaging; MR Imaging and Spectroscopy; Concluding Remarks and Outlook; References; 2: Considerations for Successful Encapsulated B-cell Therapy; Introduction; Islet Transplantation; Islet Transplantation: Site Selection Considerations. TBI and Stroke: Implications of Cell-Free Treatment Feasibility of Exosome Transplantation Therapies; Conclusion: Connecting the Dots of Stem Cell Therapy; References; 4: Cell Replacement Strategies for Parkinson's Disease; Introduction; Ventral Mesencephalon Grafting; Clinical Trial Outcomes; Stem Cell Grafting; Conclusions; References; 5: Cell Therapy for Epilepsy; Epilepsy; History; Definitions, Clinical Features, Therapeutic Needs, and Models; Cell Therapy: Direct Grafting; Introduction: Cell Types; Substitution Strategies and Bystander Effects. Increased Inhibition Strategies Limits of This Approach; Cell Therapy: Encapsulated Cell Biodelivery (ECB) Systems; Introduction: Description of the Strategy; Increased Inhibition Strategies: Galanin; Neurotrophic Factors; Delivering NTF with ECB Devices; References; 6: Dendritic Cell-Based Cancer Therapies: Current Status and Future Directions; Introduction; Dendritic Cell Subpopulations; Plasmacytoid Dendritic Cells; Conventional/Myeloid Dendritic Cells; Skin Dendritic Cells; Inflammatory DCs; Dendritic Cell Functions; Activating Signals from DCs; Inhibitory Signals from DCs.
Series Title: Molecular and translational medicine.
Responsibility: Dwaine F. Emerich, Gorka Orive, editors.

Abstract:

This volume provides a comprehensive, state-of-the art review of the field of cell therapy.  Read more...

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