Cellular and animal models in human genomics research (Book, 2019) [WorldCat.org]
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Cellular and animal models in human genomics research

Author: Katherina Walz; Juan I Young
Publisher: London, UK : Elsevier/Academic Press, 2019.
Series: Translational and applied genomics series.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters  Read more...
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Additional Physical Format: ebook version :
Document Type: Book
All Authors / Contributors: Katherina Walz; Juan I Young
ISBN: 0128165731 9780128165737
OCLC Number: 1082186992
Description: xviii, 208 pages : illustrations ; 24 cm.
Contents: Introduction to human genetics --
Disease in a dish: Cellular models to understand human conditions --
Tiny models to answer big questions: The worm and the yeast as tools in human genetics research --
Understanding human genetic disease with the fly --
Studying human genetic variation in zebrafish --
The mouse, a model organism for biomedical research --
CRISPR-Cas technology as a tool to create animal models for biomedical research --
Integrative modeling and novel technologies in human genomics --
Models to understand human genomics, final considerations
Series Title: Translational and applied genomics series.
Responsibility: edited by Katherina Walz, Juan I. Young.

Abstract:

Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. -- Provided by publisher.

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