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Cellular and molecular toxicology

Author: John P Vanden Heuvel
Publisher: Amsterdam [u.a.] : Elsevier, 2002.
Series: Comprehensive toxicology / eds.-in-chief I. Glenn Sipes ..., vol. 14.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

The growth of toxicology as a scientific discipline has been driven to a large extent by the use of powerful molecular and cell biology techniques. This book demonstrates how these advances are being  Read more...

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Genre/Form: Methods (Music)
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: John P Vanden Heuvel
ISBN: 0080423019 9780080423012 0444508686 9780444508683
OCLC Number: 248571669
Notes: Volume 14 published by Elsevier in 2002 with title: Cellular and molecular toxicology.
Description: XIII, 646 S : graph. Darst, Ill ; 28 cm.
Contents: Preface. Contributors to Volume 14. Introduction. 1. Basic Concepts. Introduction to molecular toxicology. Exposure-Dose-Response: a molecular perspective. Receptor theory and the ligand-macromolecule complex. Control of gene expression. 2. Xenobiotic Receptor Systems. Introduction and overview. The Per-Arnt-Sim (PAS) protein superfamily. The Aryl hydrocarbon receptor: a model of gene-environment interactions.Peroxisomes, peroxisome proliferators and peroxisome proliferator-activated receptors (PPARs). The physiological role of Pregnane-X-Receptor (PXR) in xenobiotic and bile acid homeostasis. Regulation of phenobarbital responsiveness via the Constitutive Androstane Receptor (CAR).Mechanisms of metal-induction of metallothionein gene expression. Modulation of soluble receptor signaling by coregulators. Convergence of multiple nuclear receptor signaling pathways in the mediation of xenobiotic-induced nongenotoxic carcinogenesis. 3. Genetic Determinants of Susceptibility to Environmental Agents.Introduction and overview. Molecular biomarkers for human liver cancer. Inherited susceptibility and prostate cancer risk. Modeling genetic susceptibility to cancer in the mouse. DNA methylation and gene silencing.4. Alterations of Cell Signaling by Xenobiotics. Introduction and overview. Mitogen-Activated Protein Kinase (MAPK) signal transduction pathways regulated by stresses and toxicants. Antioxidant induction of genes encoding detoxifying enzymes. Hypoxia regulation of gene expression through HIF1 signaling. Epigenetic-toxicant induced modulated gap junctional intercellular communication. Environmental influences on cell cycle regulation. Biochemical signals that initiate apoptosis. 5. Emerging Technologies and Predictive Assays.Introduction and overview. Bioinformatics. Interpretation of toxicogenomic data using genetically-altered mice.Gene expression analysis in the Microarray Age. Proteomic applications in toxicology. Metabonomic technology as a tool for rapid throughput in vivo toxicity screening.Data mining in toxicology.Appendix I.
Series Title: Comprehensive toxicology / eds.-in-chief I. Glenn Sipes ..., vol. 14.
Responsibility: Vols. eds $ 3010 ...
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