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Centromeres and kinetochores : discovering the molecular mechanisms underlying chromosome inheritance

Author: Ben E Black
Publisher: Cham, Switzerland : Springer International Publishing, [2017] ©2017
Series: Progress in molecular and subcellular biology, 56.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
"This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means on centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms controlling the transmission of genetic material between cell divisions and from parent to offspring. The chapters cover  Read more...
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Additional Physical Format: Erscheint auch als:
eBook
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Ben E Black
ISBN: 9783319585918 3319585916
OCLC Number: 1004772438
Description: xi, 554 pages : illustrations (chiefly color) ; 24 cm.
Contents: Part 1. Identification, Organization, and Regulation of Centromere and Kinetochore Components. Use of Mass Spectrometry to Study the Centromere and Kinetochore / Itaru Samejima, Melpomeni Platani and William C. Earnshaw --
Critical Foundation of the Kinetochore : The Constitutive Centromere-Associated Network (CCAN) / Masatoshi Hara and Tatsuo Fukagawa --
The Power of Xenopus Egg Extract for Reconstitution of Centromere and Kinetochore Function / Bradley T. French and Aaron F. Straight --
Centrochromatin of Fungi / Steven Friedman and Michael Freitag --
Evolutionary Lessons from Species with Unique Kinetochores / Ines A. Drinnenberg and Bungo Akiyoshi --
Quantitative Microscopy Reveals Centromeric Chromatin Stability, Size, and Cell Cycle Mechanisms to Maintain Centromere Homeostasis / Ana Stankovic and Lars E.T. Jansen --
Part II. Epigenetic Contributions to Centromere Identity and Function. Orchestrating the Specific Assembly of Centromeric Nucleosomes / Ewelina Zasadzińska and Daniel R. Folz --
Artificial Chromosomes and Strategies to Initiate Epigenetie Centromere Establishment / Evelyne J. Barrey and Patrick Heun --
Post-translational Modifications of Centromeric Chromatin / Ana Garcia del Arco and Sylvia Erhardt --
Centromere Silencing Mechanisms / Shannon M. McNulty and Beth A. Sullivan --
Centromere Transcription : Means and Motive / Zachary Duda, Sarah Trusiak and Rachel O'Neill --
Part III. The Role of DNA Sequence in Centromere Identity and Function. The Promises and Challenges of Genomic Studies of Human Centromeres / Karen H. Miga --
DNA Sequences in Centromere Formation and Function / M. Dumont and D. Fachinetti --
The Unique DNA Sequences Underlying Equine Centromeres / Elena Giulotto, Elena Raimondi and Kevin F. Sullivan --
Part IV. The Functions and Mechanisms of Centromeres and Kinetochores in Healthy Meiotic and Mitotic Divisions and their Role in Human Disease. Centromere Dynamics in Male and Female Germ Cells / Elaine M. Dunleavy and Caitríona M. Collins --
Cell Biology of Cheating--Transmission of Centromeres and Other Selfish Elements Through Asymmetric Meiosis / Lukáš Chmátal, Richard M. Schultz, Ben E. Black and Michael A. Lampson --
Biophysics of Microtubule End Coupling at the Kinetochore / Ekaterina L. Grishchuk --
Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing / Kevin D. Corbett --
A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC / Giulia Vallardi, Marilia Henriques Cordeiro and Adrian Thomas Saurin --
Centromeric Cohesin : Molecular Glue and Much More / Mihailo Mirkovic and Raquel A. Oliveira --
Centromere Structure and Function / Kerry Bloom and Vincenzo Costanzo --
The Role of Centromere Defects in Cancer / Thian Thian Beh and Paul Kalitsis.
Series Title: Progress in molecular and subcellular biology, 56.
Responsibility: Ben E. Black, editor.

Abstract:

"This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means on centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms controlling the transmission of genetic material between cell divisions and from parent to offspring. The chapters cover five major areas related to the current study of centromeres and kinetochores: 1) their genetic and epigenetic features, 2) key breakthroughs at the molecular, proteomic, imaging, and biochemical level, 3) the constitutive centromere proteins, 4) the role of centromere proteins in the physical process of chromosome segregation and its careful orchestration through elaborate regulation, and 5) intersections with reproductive biology, human health and disease, as well as chromosomes evolution. The book offers an informative and provacative guide for newcomers and those already acquainted with the field."--Page 4 of cover.

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