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Chamber-specific regulation of cardiac myosin, gene, and protein expression in the heart of hibernating grizzly bears, Ursus arctos horribilis

Author: Nathan D Barrows
Publisher: [Long Beach, California] : California State University, Long Beach, 2011.
Dissertation: M.S. California State University, Long Beach 2011
Series: California State University, Long Beach.; Master's thesis collection, Dept. of Biological Sciences.
Edition/Format:   Thesis/dissertation : Thesis/dissertation   Computer File : English
Summary:
Abstract: Grizzly bears, Ursus arctos horribilis, tolerate extended periods of extremely low heart rate during hibernation without developing congestive heart failure or chamber dilation. I hypothesized that relative MyHC isoform ratio would be unchanged during hibernation to maintain contractility during hibernation-associated bradycardia. Myosin heavy-chain (MyHC) proteins are the primary determinates of  Read more...
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Details

Genre/Form: Academic theses
Material Type: Thesis/dissertation, Internet resource
Document Type: Book, Computer File, Internet Resource
All Authors / Contributors: Nathan D Barrows
ISBN: 9781124607054 1124607056
OCLC Number: 1054105847
Description: vi, 66 leaves : illustrations, charts
Series Title: California State University, Long Beach.; Master's thesis collection, Dept. of Biological Sciences.
Responsibility: by Nathan D. Barrows.

Abstract:

Abstract: Grizzly bears, Ursus arctos horribilis, tolerate extended periods of extremely low heart rate during hibernation without developing congestive heart failure or chamber dilation. I hypothesized that relative MyHC isoform ratio would be unchanged during hibernation to maintain contractility during hibernation-associated bradycardia. Myosin heavy-chain (MyHC) proteins are the primary determinates of contractility, and I report a novel shift in expression toward MyHC-[alpha] isoform in the left atrium during hibernation. Interestingly, mRNA expression of atrogenes and their regulatory transcription factors is not increased in concert with ventricular atrophy, although myocardial IGF-I gene expression is decreased. Proteomic analysis of seasonal protein profiles from left atria and ventricles revealed no significant differences between groups. These findings highlight chamber-specific regulation of relative MyHC expression that may serve to optimize contractility during the altered hemodynamic state of hibernation, and suggest posttranscriptional regulation of cardiac atrophy in hibernating grizzly bears.

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