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Chemical biology of neurodegeneration : a molecular approach

Author: Pedro Merino
Publisher: Weinheim : Wiley-VCH, 2019.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on recent data on enzyme structure, mode of action, and inhibitor design,  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Merino, Pedro.
Chemical Biology of Neurodegeneration : A Molecular Approach.
Newark : John Wiley & Sons, Incorporated, ©2019
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Pedro Merino
ISBN: 9783527813452 3527813454 3527813438 9783527813421 352781342X 9783527813438
OCLC Number: 1117321409
Notes: Title from resource description page (Recorded Books, viewed September 02, 2019).
Description: 1 online resource
Contents: Neurotransmitter Systems. The Dopaminergic System --
The Noradrenergic System --
The Serotonergic System --
The Cholinergic System --
The Glutamatergic System --
The GABAergic System --
Metabolism and Proteins. Metabolism of Neurotransmitters --
Enzymes Processing Neurotransmitters --
Misfolded Proteins --
Therapeutic Agents for Neurodegenerative Disorders.
Responsibility: Pedro Merino.

Abstract:

Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on recent data on enzyme structure, mode of action, and inhibitor design, it describes'from a biochemical point of view'the six most important neurotransmitter systems and their constituent enzymes and receptors. Misfolding and aggregation of proteins within the brain is also covered. In addition, the book surveys a wide range of proven and prospective therapeutic agents that modulate key processes in the brain, from their chemical synthesis to their mode of action in model systems as well as in the patient. Chemical Biology of Neurodegeneration: A Molecular Approach is presented in two parts. The first introduces the neurotransmitter systems and provides a general explanation of the synapse and a description of the main structures involved in neurotransmission that can be considered therapeutic targets for disorders of the central nervous system. The second part presents molecular and chemical aspects directly involved or affected in neurodegeneration, including the metabolism of neurotransmitters, enzymes processing neurotransmitters, protein misfolding, and therapeutic agents.-Uses an interdisciplinary approach to bridge the gap between the basic biochemical events in a nerve cell and their neurological effects on the brain -Places emphasis on the chemistry of small molecule modulators that are potential lead molecules for new drugs -Covers six key neurotransmitter systems and their enzymes and receptors'dopaminergic, noradrenergic, serotonergic, cholinergic, GABaergic, and glutamatergic Chemical Biology of Neurodegeneration: A Molecular Approach is a key resource for medicinal chemists, neurobiologists, neurochemists, biochemists, molecular biologists, and nEurophysiologists.

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