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Chemical mixtures and combined chemical and nonchemical stressors : exposure, toxicity, analysis, and risk

Author: Cynthia V Rider; Jane Ellen Simmons; Linda S Birnbaum
Publisher: Cham, Switzerland : Springer, [2018] ©2018
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Exposure to multiple chemical and nonchemical stressors is the rule, not the exception. Nevertheless, it continues to be a significant challenge in toxicology and risk assessment to thoroughly take mixtures into account. In this book, both basic and advanced concepts for considering mixtures are discussed, from initial-exposure characterization through the evaluation of risk associated with combined exposures.  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Printed edition:
(OCoLC)1044962330
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Cynthia V Rider; Jane Ellen Simmons; Linda S Birnbaum
ISBN: 9783319562346 3319562347
OCLC Number: 1023628326
Description: 1 online resource (xiv, 556 pages) : illustrations (some color)
Contents: Introduction --
Combined exposures --
Biomonitoring to assess exposures to mixtures of environmental chemicals --
Considerations for measuring exposures to chemical mixtures --
Modeling complex exposures --
Prioritizing mixtures for study --
Introduction to environment and exposome-wide association studies: A data-driven method to identify multiple environmental factors associated with phenotpyes in human populations --
Ecological assembly of chemical mixtures --
Adverse outcome pathways to support the assessment of chemical mixtures --
Toxicology --
Dose-response modeling --
Predicting mixture toxicity with models of additivity --
Mixtures: contrasting perspectives from toxicology and epidemiology --
Comparing predicted additivity models to observed mixture data --
Physiologically based parmacokinetic modeling of chemical mixtures --
Mixture experimental design --
Chemical mixtures risk assessment --
Component-based risk assessment approaches with addivity and interactions --
Assessing human health risks using information on whole mixtures --
Nonchemical stressors --
Consideration of physical stressors in cumulative risk assessment --
Psychosocial and chemical stressors --
Community-based cumulative impact assessment: California's approach to integrating nonchemical stressors into environmental assessment practices.
Responsibility: Cynthia V. Rider, Jane Ellen Simmons, editors ; foreword by Linda S. Birnbaum.

Abstract:

In this book, both basic and advanced concepts are discussed for considering mixtures from initial exposure characterization through evaluation of risk associated with combined exposures.  Read more...

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