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Chemical stability of pharmaceuticals : a handbook for pharmacists

Author: Kenneth A Connors; Gordon L Amidon; Valentino J Stella
Publisher: New York : Wiley, ©1986.
Edition/Format:   Print book : English : 2nd edView all editions and formats
Summary:
"Provides a sound theoretical basis for understanding chemical kinetics and its uses in studying drug stability. Treats the calculations, approximations, and estimates that are useful to the pharmacist in professional practice, and presents a collection of selected drug-stability data from the pharmaceutical literature. This Handbook makes accessible to the pharmacist much of the information necessary to make  Read more...
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Genre/Form: Handbook
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Kenneth A Connors; Gordon L Amidon; Valentino J Stella
ISBN: 047187955X 9780471879558
OCLC Number: 13008905
Notes: "A Wiley-Interscience publication."
Description: xii, 847 pages : illustrations ; 24 cm
Contents: Part One. Principles. Chapter 1. Introduction. A. Stability prediction by the pharmacist; B. Other sources of information --
Chapter 2. Stability calculations. A. Rate equations; B. Temperature effects --
Chapter 3. Interpretation of kinetic data. A. The transition-state theory; B. Medium effects; C. Catalysis; D. ph Effects; E. Some practical matters --
Chapter 4. Hydrolysis and other acyl transfers. A. Nature of the reaction; B. Catalysis; C. Structure and reactivity; D. Stabilization of pharaceuticals; E. Pharmaceutical examples --
Chapter 5. Oxidation and photolysis. A. Oxidation; B. Photolysis --
Chapter 6. Solid-state chemical decomposition. A. Kinetics of solid-state decomposition; B. Pharmaceutical examples of solid-state decomposition; C. Methods of stabilization --
Chapter 7. Strategy and tactics of stability testing. A. Regulatory requirements; B. Stability protocols; C. Interpretation of data --
Part Two. Stability monographs.
Responsibility: Kenneth A. Connors, Gordon L. Amidon, Valentino J. Stella.
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Abstract:

Provides a sound theoretical basis for understanding chemical kinetics and its uses in studying drug stability. Treats the calculations, approximations, and estimates that are useful to the  Read more...

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