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Childhood acute lymphoblastic leukemia

Author: Ajay Vora
Publisher: Cham, Switzerland : Springer, 2017.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Childhood acute lymphoblastic leukemia.
Cham, Switzerland : Springer, 2017
(OCoLC)948547428
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ajay Vora
ISBN: 9783319397085 3319397087
OCLC Number: 984342596
Notes: Includes index.
Description: 1 online resource (ix, 342 pages) : illustrations (some color)
Contents: Contributors; Chapter 1: Epidemiology and Etiology of Childhood ALL; 1.1 Introduction; 1.2 General Epidemiology; 1.3 Natural History; 1.4 Environmental Risk Factors; 1.4.1 Infectious Disease and Immune Stimulation; 1.4.2 Other Risk Factors; 1.5 Heritability of ALL; 1.6 High-Penetrance Genetic Predisposition; 1.6.1 Syndromes Where ALL Is a Dominant Cancer Phenotype; 1.6.2 Syndromes Where ALL Is Part of a Mixed Cancer Phenotype; 1.7 Low-Penetrance Genetic Predisposition; 1.8 Future Directions; References; Chapter 2: Clinical Presentation and Prognostic Factors. 2.1 Clinical Presentation2.1.1 Introduction; 2.1.2 Symptoms and Signs Related to Bone Marrow Involvement; 2.1.3 Symptoms and Signs Related to Extensive Bulk Disease; 2.1.4 Central Nervous System; 2.1.5 The Eye; 2.1.6 Genitourinary System; 2.1.7 Cardiovascular System; 2.1.8 The Skin; 2.1.9 Head and Neck; 2.1.10 Gastrointestinal System; 2.1.11 Hypercalcaemia; 2.1.12 Haemophagocytic Lymphohistiocytosis (HLH); 2.1.13 Aplastic Presentation; 2.1.14 Rare Presentations; 2.1.15 Asymptomatic Pancytopenia; 2.1.16 The Diagnostic Interval and Pathway; 2.1.17 Differential Diagnosis; 2.2 Laboratory Features. 2.2.1 Haematology2.2.2 Biochemistry; 2.2.3 Bone Marrow Aspirate; 2.2.4 Lumbar Puncture; 2.3 Diagnostic Workup; 2.4 Prognostic Factors; 2.5 Individual Prognostic Factors; 2.5.1 Age; 2.5.2 White Cell Count; 2.5.3 NCI Risk Score; 2.5.4 Gender; 2.5.5 CNS Disease; 2.5.6 Disease Bulk; 2.5.7 Immunophenotype; 2.5.8 Genetics; 2.5.9 Response to Treatment; References; Chapter 3: Diagnostic Flow Cytometry and Immunophenotypic Classification; 3.1 Introduction; 3.2 Immunophenotype of T-Lymphoblastic Leukemia/Lymphoma; 3.3 Early T-Cell Precursor ALL; 3.4 Immunophenotype of B-Lymphoblastic Leukemia/Lymphoma. 3.5 Acute Leukaemia of Ambiguous Lineage3.6 Antigen Expression: Correlation to Prognosis and Cytogenetics; 3.7 Extended Leukaemia Immunophenotyping; 3.8 Conclusions and Perspective; References; Chapter 4: Cytogenetics and Molecular Genetics; 4.1 Introduction; 4.2 Abnormality Detection Methodologies; 4.3 Chromosomal Abnormalities in BCP-ALL; 4.3.1 Favourable Risk Abnormalities; 4.3.1.1 High Hyperdiploidy; 4.3.1.2 t(12; 21)(p13; q22)/ETV6-RUNX1; 4.3.1.3 t(1; 19)(q23; p13)/TCF3-PBX1; 4.3.2 Poor-Risk Chromosomal Abnormalities; 4.3.2.1 t(9; 22)(q34; q11.1)/BCR-ABL1; 4.3.2.2 t(17; 19)(q22. P13)/TCF3-HLF4.3.2.3 11q23/KMT2A Gene Rearrangements; 4.3.2.4 Near-Haploidy and Low Hypodiploidy; 4.3.2.5 Intrachromosomal Amplification of Chromosome 21 (iAMP21); 4.3.3 B-ALL Lacking Sentinel Chromosomal Rearrangements; 4.3.3.1 Ph-Like or BCR-ABL1-Like ALL; 4.3.3.2 CRLF2 Rearrangements and Janus Kinase Mutations in ALL; 4.3.3.3 DUX4 and ERG-Deregulated ALL; 4.3.3.4 Translocations Involving the IGH Locus; 4.3.3.5 PAX5 Rearrangements; MEF2D and ZNF384 Gene Fusions; ETV6-RUNX1-Like; 4.3.4 Secondary Genetic Alterations in BCP-ALL; 4.4 Genetic Rearrangements in T-Lineage ALL.
Responsibility: Ajay Vora, editor.

Abstract:

This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care.  Read more...

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"The purpose is to provide an in-depth look at the complex disease of childhood ALL. ... a concise resource such as this can be used by many medical professionals such as physicians, advanced Read more...

 
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