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Cutting-edge organic synthesis and chemical biology of bioactive molecules : the shape of organic synthesis to come

Author: Yuichi Kobayashi
Publisher: Singapore : Springer, [2019]
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Printed edition:
Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Yuichi Kobayashi
ISBN: 9789811362446 9811362440 9811362432 9789811362439 9789811362453 9811362459 9789811362460 9811362467
OCLC Number: 1103320252
Description: 1 online resource.
Contents: 1. Microbial Fraction Library: A Screening Source for Drug Discovery --
2. Efficient Total Synthesis of Ōmura Natural Products --
3. Enantioselective Total Synthesis of the Antitumor Polycyclic Natural Products, FR182877 and Taxol --
4. Synthetic Approaches on the Pluramycin-class Antibiotics --
5. Recent Progress Toward the Total Synthesis of Duocarmaycins A and SA, Yatakemaycin, and PDE-I and –II --
6. Structure-Activity Relationship Studies of Maitotoxin Based on Chemical Synthesis --
7. Substitution of Allylic Picolinates with Various Copper Reagents and Synthetic Applications --
8. Total Synthesis of Ingenol --
9. Strategies for Synthesis of Anti-inflammatory Metabolites of Unsaturated Fatty Acids --
10. Biosynthesis, biological functions, and receptors of leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid --
11. Synthesis of classical/non-classical hybrid cannabinoids and related compounds --
12. Exploring bioactive marine natural products and identification of their molecular targets --
13. Target protein chemical modification --
14. Target Identification of Bioactive Compounds by Photoaffinity Labeling Using Diazido Probes.
Responsibility: editor, Yuichi Kobayashi.

Abstract:

This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical  Read more...

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