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Delivery of therapeutics for biogerontological interventions : from concepts to experimental design

Author: Wing-Fu Lai
Publisher: London : Academic Press, 2019.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Genre/Form: Electronic books
Additional Physical Format: Print version:
(OCoLC)1089004236
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Wing-Fu Lai
ISBN: 9780128172766 0128172762
OCLC Number: 1110488735
Description: 1 online resource
Contents: Front Cover; Delivery of Therapeutics for Biogerontological Interventions; Copyright Page; Contents; Foreword; Preface; Abbreviations; I. From Concepts to Plans; 1 Theoretical frameworks for intervention development; Introduction; A reductionist approach to understand aging; Reliability theory of aging; Hypothetical frameworks for tackling aging; Reasons for the failure of an intervention; Summary; References; 2 Available delivery technologies for intervention execution; Introduction; Use of delivery technologies in interventions; Advances in delivery of nucleic acids Nucleic acid delivery mediated by biological meansNucleic acid delivery mediated by chemical and physical means; Advances in delivery of nongenetic materials; Integration of engineering techniques into therapeutics delivery; Summary; References; II. From Plans to Technologies; 3 Design of viral vectors for genetic manipulation; Introduction; Engineering the properties of a viral vector; Chemical manipulation for controlled delivery; Applications in genetic manipulation; Opportunities and challenges; Summary; References; 4 Design of polymeric vectors for genetic manipulation; Introduction Selection of polymeric vectorsStructural modification of polymeric vectors; Copolymerization; Functional group modification; Ligand conjugation; Optimization for intervention execution; Summary; References; 5 Design of cyclodextrin-based systems for intervention execution; Introduction; Basic properties of cyclodextrins; Strategies for structural engineering of cyclodextrins; Roles in vector design; Cyclodextrin incorporation for multifunctionality; Manipulation of host-guest complexation; Summary; References; 6 Design of upconversion nanoparticles for intervention execution; Introduction Major designing principlesFabrication and morphological manipulation of upconversion nanoparticles; Generation of upconversion nanoparticle-based nucleic acid carriers; Roles of upconversion nanoparticles in nucleic acid delivery; Light-mediated control of intervention execution; Imaging and tracking of the delivery process; Optimization of upconversion nanoparticle-based nucleic acid carriers; Improvement in upconversion nanoparticle fabrication; Summary; References; 7 Design of hydrogel-based nanoparticles for intervention execution; Introduction; Development of hydrogels for drug delivery Design of hydrogels for intervention developmentGeneration of hydrogel nanoparticles; Ring-opening polymerization; Aqueous dispersion polymerization; Emulsion polymerization; Methods for drug loading; Strategies for cargo loading; Factors influencing the loading efficiency; Modulation of drug release; Summary; References; III. From Technologies to Interventions; 8 Use of delivery technologies to mediate RNA degradation; Introduction; Manipulation of the aging network by RNAi; Enhancement of the siRNA performance; Delivery of siRNA therapeutics; Clinical use of siRNA therapeutics
Responsibility: Wing-Fu Lai.

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