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Development of antibody-based therapeutics : translational considerations & challenges

Author: Mohammad A Tabrizi; Gadi G Bornstein; Scott L Klakamp
Publisher: Singapore : Adis, [2018]
Edition/Format:   eBook : Document : English : Second editionView all editions and formats
Summary:
This book examines vital considerations in designing effective translational strategies in the development of antibody-based therapeutics, including the relationship between the 'unit dose' and 'unit effect' with respect to beneficial and deleterious effects.
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Genre/Form: Electronic books
Additional Physical Format: (OCoLC)1030909638
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Mohammad A Tabrizi; Gadi G Bornstein; Scott L Klakamp
ISBN: 9789811304965 9811304963
OCLC Number: 1052613030
Description: 1 online resource.
Contents: Introduction --
Translational considerations and challenges : an overview --
Considerations for construct and affinity design goals --
Epitope characterization and isotype selection --
Biophysical considerations for development of antibody-based therapeutics --
Novel technologies for generation of bispecific constructs --
Stimulus-response mechanisms : an overview --
Evaluation of tumor growth inhibition in preclinical tumor models : a quantitative approach --
Application of proof-of-mechanism biomarkers (POM) in design and development of biologics modalities --
Antibody drug conjugates : translational considerations --
Application of PK-PD modeling and simulation approaches for immuno-oncology drugs --
Translational biomarkers : application in the clinical development of combination therapies --
Correction to : considerations for construct and affinity design goals.
Responsibility: Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp, editors.

Abstract:

This book examines vital considerations in designing effective translational strategies in the development of antibody-based therapeutics, including the relationship between the 'unit dose' and 'unit  Read more...

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