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Développement d'approches d'imagerie multimodale pour la recherche en oncologie

Author: Jonathan LavaudAnnie MollaJean-Luc CracowskiThierry BettingerAnabela Da SilvaAll authors
Publisher: 2018.
Dissertation: Thèse de doctorat : Chimie biologie : Université Grenoble Alpes (ComUE) : 2018.
Edition/Format:   Computer file : Document : Thesis/dissertation : French
Summary:
L'imagerie préclinique in vivo en oncologie représente un outil de choix pour étudier lesmécanismes qui régissent cette pathologie mais également pour évaluer des solutionsdiagnostiques et thérapeutiques innovantes. Chaque modalité d'imagerie possède sespropres atouts et limites et c'est pourquoi il existe un réel bénéfice à associer plusieursmodalités pour recueillir des informations
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Genre/Form: Thèses et écrits académiques
Material Type: Document, Thesis/dissertation, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Jonathan Lavaud; Annie Molla; Jean-Luc Cracowski; Thierry Bettinger; Anabela Da Silva; Anikitos Garofalakis; Véronique Josserand; Communauté d'universités et d'établissements Université Grenoble Alpes.; École doctorale chimie et science du vivant (Grenoble).; Institut pour l'avancée des biosciences (Grenoble).
OCLC Number: 1096188721
Notes: Titre provenant de l'écran-titre.
Description: 1 online resource
Responsibility: Jonathan Lavaud ; sous la direction de Annie Molla.

Abstract:

L'imagerie préclinique in vivo en oncologie représente un outil de choix pour étudier lesmécanismes qui régissent cette pathologie mais également pour évaluer des solutionsdiagnostiques et thérapeutiques innovantes. Chaque modalité d'imagerie possède sespropres atouts et limites et c'est pourquoi il existe un réel bénéfice à associer plusieursmodalités pour recueillir des informations complémentaires. Dans la première partie de cetravail, la combinaison de l'imagerie de fluorescence 3-D avec l'imagerie microCT a été miseen oeuvre et s'est montrée particulièrement pertinente pour la caractérisation de différentsmodèles animaux de cancers pulmonaires représentant chacun spécifiquement une ouplusieurs étapes du développement tumoral primaire à l'invasion métastatique. Dans uneseconde partie, nous avons évalué le potentiel de l'imagerie photoacoustique pourl'imagerie non-invasive de la vascularisation et de l'oxygénation tissulaire dans différentscontextes physiopathologiques chez la souris ainsi que chez l'homme, démontrant ainsi sonfort potentiel translationnel. Des agents de contrastes fluorescents et photoacoustiques ontété utilisés pour augmenter le contraste tumoral et suivre les variations de niveaud'expression de biomarqueurs d'intérêt et le bénéfice apporté par l'utilisation d'unmarqueur présentant une spécificité tumorale a été démontré. En parallèle des étudesbiologiques, des développements technologiques en imagerie photoacoustique ont étéinitiés en vue d'améliorer le potentiel applicatif de cette modalité d'imagerie.

In vivo preclinical imaging in oncology is a tool of choice to study the mechanisms thatgovern this pathology as well as for the evaluation of innovative diagnostic and therapeuticsolutions. Each imaging modality has its own strengths and limitations and that's why thereis a real benefit to combine several modalities to collect complementary information. In thefirst part of this work, the combination of 3-D fluorescence imaging with microCT imaginghas been implemented and has been particularly relevant for the characterization ofdifferent animal models of lung cancer mimicking one or several stages from primary tumordevelopment to metastatic invasion. In a second part, we assessed the potential ofphotoacoustic imaging for non-invasive imaging of vascularization and tissue oxygenation indifferent pathophysiological contexts in mice as well as in humans, thus demonstrating itshigh translational potential. Fluorescent and photoacoustic contrast agents have been usedto increase tumor contrast and monitor changes in the level of expression of biomarkers ofinterest and the benefit provided by the use of a tumor specific marker has beendemonstrated. In parallel with biological studies, technological developments inphotoacoustic imaging have been initiated in order to improve the application potential ofthis imaging modality.

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Primary Entity<\/h3>\n
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Dans la premi\u00E8re partie de cetravail, la combinaison de l\'imagerie de fluorescence 3-D avec l\'imagerie microCT a \u00E9t\u00E9 miseen oeuvre et s\'est montr\u00E9e particuli\u00E8rement pertinente pour la caract\u00E9risation de diff\u00E9rentsmod\u00E8les animaux de cancers pulmonaires repr\u00E9sentant chacun sp\u00E9cifiquement une ouplusieurs \u00E9tapes du d\u00E9veloppement tumoral primaire \u00E0 l\'invasion m\u00E9tastatique. Dans uneseconde partie, nous avons \u00E9valu\u00E9 le potentiel de l\'imagerie photoacoustique pourl\'imagerie non-invasive de la vascularisation et de l\'oxyg\u00E9nation tissulaire dans diff\u00E9rentscontextes physiopathologiques chez la souris ainsi que chez l\'homme, d\u00E9montrant ainsi sonfort potentiel translationnel. 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<http:\/\/experiment.worldcat.org\/entity\/work\/data\/9027129378#Person\/molla_annie<\/a>> # Annie Molla<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Molla<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Annie<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Annie Molla<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
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<http:\/\/experiment.worldcat.org\/entity\/work\/data\/9027129378#Topic\/biotechnologie<\/a>> # Biotechnologie<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Biotechnologie<\/span>\"@fr<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
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<http:\/\/experiment.worldcat.org\/entity\/work\/data\/9027129378#Topic\/optique<\/a>> # Optique<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Optique<\/span>\"@fr<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/9027129378#Topic\/ultrasons<\/a>> # Ultrasons<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Ultrasons<\/span>\"@fr<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/id.loc.gov\/vocabulary\/countries\/fr<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:Place<\/a> ;\u00A0\u00A0\u00A0\ndcterms:identifier<\/a> \"fr<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/www.theses.fr\/2018GREAV052\/document<\/a>>\u00A0\u00A0\u00A0\nrdfs:comment<\/a> \"Acc\u00E8s au texte int\u00E9gral<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/www.worldcat.org\/title\/-\/oclc\/1096188721<\/a>>\u00A0\u00A0\u00A0\u00A0a \ngenont:InformationResource<\/a>, genont:ContentTypeGenericResource<\/a> ;\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/www.worldcat.org\/oclc\/1096188721<\/a>> ; # D\u00E9veloppement d\'approches d\'imagerie multimodale pour la recherche en oncologie<\/span>\n\u00A0\u00A0\u00A0\nschema:dateModified<\/a> \"2020-10-07<\/span>\" ;\u00A0\u00A0\u00A0\nvoid:inDataset<\/a> <http:\/\/purl.oclc.org\/dataset\/WorldCat<\/a>> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n\n

Content-negotiable representations<\/p>\n