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Diagnostic and therapeutic applications of exosomes in cancer

Author: Mansoor M Amiji; Rajagopal Ramesh
Publisher: London, United Kingdom : Academic Press, 2018.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Genre/Form: Electronic books
Additional Physical Format: (OCoLC)1007045522
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Mansoor M Amiji; Rajagopal Ramesh
ISBN: 9780128128046 0128128046
OCLC Number: 1035556367
Notes: Includes index.
Description: 1 online resource.
Contents: Intro; Title page; Table of Contents; Copyright; Dedication; List of Contributors; Preface; Acknowledgments; 1. Introduction to Exosomes and Cancer; 1. A Brief History; 2. Biogenesis; 3. Isolation and Characterization; 4. Content; 5. Biological Function in Cancer; 2. Extracellular Vesicle Biogenesis in Cancer; 1. Introduction; 2. Microvesicle Biogenesis; 3. Exosome Biogenesis; 4. An Increasing Importance of Examining Diverse Vesicles; 5. CD63-Dependent Vesicle Production; 6. Vesicle Secretion Is Linked to Intercellular Signaling 3. Composition, Physicochemical and Biological Properties of Exosomes Secreted From Cancer Cells1. Introduction; 2. Exosome Biogenesis; 3. Factors Affecting the Release of Exosomes From Cancer Cells; 4. Composition of Exosomes; 5. Size and Charge of Cancer Exosomes; 6. Summary and Future Considerations; 4. Heterogeneity of Tumor Exosomes --
Role in Precision Medicine; 1. Introduction; 2. Double-Stranded Genomic DNA in Circulating Exosomes; 3. Detection of Mutational Signatures in Genomic DNA-Enriched Exosomes; 4. Exosomes as Agents for Early Detection, Diagnosis, and Stratification 5. Genomic Molecular Profiling of Exosomal Cargo6. Transcriptomic Characterization of Tumors Through Liquid Biopsies; 7. Conclusions; 5. Proteomic Profiling of Tumor Exosomes; 1. Introduction; 2. Sources of Exosomes; 3. Proteomic Content of Exosomes in Cancers; 4. Conclusion; 6. Nucleic Acid Profiling in Tumor Exosomes; 1. Introduction; 2. Composition of Exosomes; 3. Nucleic Acid Loading Into Exosomes; 4. Isolation Techniques for RNA/DNA From Exosomes; 5. Profiling of Nucleic Acid-RNA; 6. Single EV Analysis; 7. Statistical and Bioinformatic Software for evRNA Characterization 8. Experimental Artifacts and Contaminants Affecting evRNA Analysis9. Conclusions; 7. Nanotechnology Platforms for Cancer Exosome Analyses; 1. Introduction; 2. Nanoplasmonic Sensing; 3. Electrochemical Sensing; 4. Immunomagnetic Exosome RNA Analysis; 5. Conclusions; 8. Exosome RNAs as Biomarkers and Targets for Cancer Therapy; 1. Introduction; 2. History of RNA in Exosomes; 3. RNA Species Present in Exosomes; 4. Sources of Exosomes; 5. Technology for the Study of Exosomal miRNA; 6. Challenges and Perspective; 7. Conclusion; 9. Diagnostic Potential of Tumor Exosomes; 1. Introduction 2. Methods and Tools for Exosome Isolation3. Tumor Exosomes for Cancer Diagnosis; 4. Additional Diagnostic Potential of Exosomes; 5. Conclusion/Discussion; 10. Biodistribution of Cancer-Derived Exosomes; 1. Introduction; 2. Mechanisms Involved in Tumor-Derived Exosomes Homing to Specific Organs; 3. Impact of Diverse Factors on the Evaluation of Exosome Biodistribution In Vivo; 4. Conclusions; 11. Exosome-Mediated Communication in the Tumor Microenvironment; 1. Introduction; 2. Exosomes and the Tumor Microenvironment; 3. Exosome-Mediated Cellular Reprogramming; 4. Future Prospects
Responsibility: edited by Mansoor Amiji, Rajagopal Ramesh.

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