skip to content
Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention.
ClosePreview this item
Checking...

Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention.

Author: GL Russo Affiliation: Institute of Food Sciences, National Research Council, 83100 Avellino, Italy. glrusso@isa.cnr.it
Edition/Format: Article Article : English
Publication:Biochemical pharmacology, 2009 Mar 15; 77(6): 937-46
Other Databases: WorldCat
Summary:
Linoleic acid (LA) and alpha linolenic acid (ALA) belong to the n-6 (omega-6) and n-3 (omega-3) series of polyunsaturated fatty acids (PUFA), respectively. They are defined "essential" fatty acids since they are not synthesized in the human body and are mostly obtained from the diet. Food sources of ALA and LA are most vegetable oils, cereals and walnuts. This review critically revises the most significant  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

&AllPage.SpinnerRetrieving;

Find a copy online

Links to this journal/publication

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Document Type: Article
All Authors / Contributors: GL Russo Affiliation: Institute of Food Sciences, National Research Council, 83100 Avellino, Italy. glrusso@isa.cnr.it
ISSN:0006-2952
Language Note: English
Unique Identifier: 317047938
Awards:

Abstract:

Linoleic acid (LA) and alpha linolenic acid (ALA) belong to the n-6 (omega-6) and n-3 (omega-3) series of polyunsaturated fatty acids (PUFA), respectively. They are defined "essential" fatty acids since they are not synthesized in the human body and are mostly obtained from the diet. Food sources of ALA and LA are most vegetable oils, cereals and walnuts. This review critically revises the most significant epidemiological and interventional studies on the cardioprotective activity of PUFAs, linking their biological functions to biochemistry and metabolism. In fact, a complex series of desaturation and elongation reactions acting in concert transform LA and ALA to their higher unsaturated derivatives: arachidonic acid (AA) from LA, eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) from ALA. EPA and DHA are abundantly present in fish and fish oil. AA and EPA are precursors of different classes of pro-inflammatory or anti-inflammatory eicosanoids, respectively, whose biological activities have been evoked to justify risks and benefits of PUFA consumption. The controversial origin and clinical role of the n-6/n-3 ratio as a potential risk factor in cardiovascular diseases is also examined. This review highlights the important cardioprotective effect of n-3 in the secondary prevention of sudden cardiac death due to arrhythmias, but suggests caution to recommend dietary supplementation of PUFAs to the general population, without considering, at the individual level, the intake of total energy and fats.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/317047938> # Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention.
    a schema:CreativeWork, schema:Review, schema:Article ;
    library:oclcnum "317047938" ;
    rdfs:comment "949 $l Journal Article" ;
    rdfs:comment "949 $l Research Support, Non-U.S. Gov't" ;
    schema:creator <http://experiment.worldcat.org/entity/work/data/192657342#Person/russo_gl> ; # Russo GL
    schema:description "Linoleic acid (LA) and alpha linolenic acid (ALA) belong to the n-6 (omega-6) and n-3 (omega-3) series of polyunsaturated fatty acids (PUFA), respectively. They are defined "essential" fatty acids since they are not synthesized in the human body and are mostly obtained from the diet. Food sources of ALA and LA are most vegetable oils, cereals and walnuts. This review critically revises the most significant epidemiological and interventional studies on the cardioprotective activity of PUFAs, linking their biological functions to biochemistry and metabolism. In fact, a complex series of desaturation and elongation reactions acting in concert transform LA and ALA to their higher unsaturated derivatives: arachidonic acid (AA) from LA, eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) from ALA. EPA and DHA are abundantly present in fish and fish oil. AA and EPA are precursors of different classes of pro-inflammatory or anti-inflammatory eicosanoids, respectively, whose biological activities have been evoked to justify risks and benefits of PUFA consumption. The controversial origin and clinical role of the n-6/n-3 ratio as a potential risk factor in cardiovascular diseases is also examined. This review highlights the important cardioprotective effect of n-3 in the secondary prevention of sudden cardiac death due to arrhythmias, but suggests caution to recommend dietary supplementation of PUFAs to the general population, without considering, at the individual level, the intake of total energy and fats." ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/192657342> ;
    schema:isPartOf <http://worldcat.org/issn/0006-2952#77_6> ;
    schema:name "Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention." ;
    schema:pageStart "937" ;
    schema:productID "317047938" ;
    schema:sameAs <http://dx.doi.org/10.1016/j.bcp.2008.10.020> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/317047938> ;
    .


Related Entities

<http://worldcat.org/issn/0006-2952>
    a schema:Periodical ;
    rdfs:label "Biochemical pharmacology" ;
    schema:issn "0006-2952" ;
    .

<http://www.worldcat.org/title/-/oclc/317047938>
    a genont:InformationResource, genont:ContentTypeGenericResource ;
    schema:about <http://www.worldcat.org/oclc/317047938> ; # Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention.
    schema:dateModified "2016-06-30" ;
    void:inDataset <http://purl.oclc.org/dataset/medline> ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.