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Discovery and analysis of long noncoding RNAs in the DNA damage response

Author: Tiffany HungHoward ChangAndrew Zachary FirePaul A KhavariJoanna Wysocka, Ph. D.All authors
Publisher: 2012.
Dissertation: Ph. D. Stanford University 2012
Edition/Format:   Thesis/dissertation : Document : Thesis/dissertation : eBook   Computer File : English
Summary:
Recent advances in transcriptome analysis have revealed a large number of non-protein coding transcripts that have previously been uncharacterized. A subset of these molecules, termed long noncoding RNAs (lncRNAs), has been implicated in the regulation of chromatin states. Here, we detail a journey of lncRNA discovery and analysis, beginning from the de novo discovery of lncRNAs within the promoters of cell cycle  Read more...
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Details

Genre/Form: Academic theses
Material Type: Document, Thesis/dissertation, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Tiffany Hung; Howard Chang; Andrew Zachary Fire; Paul A Khavari; Joanna Wysocka, Ph. D.; Stanford University. Cancer Biology Program.
OCLC Number: 809264384
Notes: Submitted to the Program in Cancer Biology.
Description: 1 online resource
Responsibility: Tiffany Hung.

Abstract:

Recent advances in transcriptome analysis have revealed a large number of non-protein coding transcripts that have previously been uncharacterized. A subset of these molecules, termed long noncoding RNAs (lncRNAs), has been implicated in the regulation of chromatin states. Here, we detail a journey of lncRNA discovery and analysis, beginning from the de novo discovery of lncRNAs within the promoters of cell cycle genes, followed by the functional characterization of select candidates. We characterize two examples that regulate the p53-mediated DNA damage response. LncRNA PANDA blocks the apoptosis pathway by inhibiting the transcription factor NF-YA, and lncRNA DINO regulates the p53 transcriptional response by regulating SET7-mediated post-translational modification. Altogether, these studies support a model whereby pervasive lncRNA transcripts, previously discarded as transcriptional byproducts, function through diverse mechanisms as critical regulators of biological pathways.

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Primary Entity

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