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The Drosophila model in cancer

Author: Wu-Min Deng
Publisher: Cham : Springer, 2019.
Series: Advances in experimental medicine and biology, v. 1167.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly models genetic simplicity and the  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Deng, Wu-Min.
Drosophila Model in Cancer.
Cham : Springer, ©2019
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Wu-Min Deng
ISBN: 9783030236298 3030236293
OCLC Number: 1120694155
Notes: 5.8 Tumor Hotspots, a Tissue-Intrinsic Oncogenic Niche
Includes index.
Description: 1 online resource (250 pages)
Contents: Intro; Contents; 1: Drosophila Model in Cancer: An Introduction; 1.1 Introduction; 1.1.1 Genetic Tools Available in Drosophila; 1.1.2 The Use of Drosophila to Identify Cancer Related Genes and Pathways; 1.1.3 Drosophila as a "Whole Animal" Model System to Study Human Cancer; 1.1.4 Emerging Concepts from Drosophila Studies in Cancer; 1.1.5 Translational Aspects of Cancer Research in Drosophila; 1.2 Concluding Remarks; References; 2: Using Drosophila Models and Tools to Understand the Mechanisms of Novel Human Cancer Driver Gene Function; 2.1 Introduction 3: Drosophila Models of Cell Polarity and Cell Competition in Tumourigenesis3.1 Cell Competition; 3.2 Cell Polarity Regulator Proteins and Cell Competition; 3.2.1 Scribbled and Discs Large 1; 3.2.1.1 Signalling Pathways Regulating Cell Competition; 3.2.1.2 Systems to Sense Cell Fitness Between Neighbouring Cells; 3.2.1.3 Systems to Eliminate the Loser Cells During Competition; 3.2.2 Lethal (2) Giant Larvae; 3.2.2.1 Elimination of l(2)gl Mutant Clones Is Tissue Dependent; 3.2.2.2 Elimination of l(2)gl Mutant Clones in the Wing Epithelium Is Myc Dependent; 3.2.2.3 Mahjong 3.2.3 Crumbs3.2.3.1 Crumbs Alteration Can Induce Competitor or Super-Competitor Behaviours; 3.2.3.2 The Mechanism of Crb in Cell Competition; 3.2.4 Cell Competition During Cooperative Tumourigenesis; 3.3 Conclusions and Future Directions; References; 4: Two Sides of the Same Coin --
Compensatory Proliferation in Regeneration and Cancer; 4.1 Introduction --
Caspase-Driven Compensatory Proliferation: Coupling Apoptosis, Regeneration and Cancer; 4.2 Compensatory Proliferation: Studies in Drosophila melanogaster; 4.3 Compensatory Proliferation in Regeneration of Different Model Organisms 4.4 The "Dark Side" of Compensatory Proliferation: Role in Promoting Cancer4.5 Conclusions; References; 5: The Initial Stage of Tumorigenesis in Drosophila Epithelial Tissues; 5.1 Introduction; 5.2 Oncogenic Transformation; 5.3 Competitive Interaction Between Pro-Tumor Cells and Their Neighbors; 5.4 Misoriented Cell Division as an Initiator of Tumorigenesis; 5.5 The Cell Cycle Regulation of the Ovarian Follicle Cells; 5.6 Reintegration of Misplaced Cells as an Error-Correction System; 5.7 Tumorigenesis Induced by Endocytic TSGs Defects
Series Title: Advances in experimental medicine and biology, v. 1167.
Responsibility: Wu-Min Deng, editor.

Abstract:

This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly models genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.

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