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Drug metabolism in drug design and development : basic concepts and practice

Author: Donglu Zhang; Mingshe Zhu; W Griffith Humphreys
Publisher: Hoboken, N.J. : Wiley-Interscience, ©2008.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
'Drug Metabolism in Drug Design and Development' provides a practical description of what happens during the drug design and development process and focuses on issues such as: what data are needed, what experiments and analytical methods are typically employed, and how to interpret and apply data.
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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Donglu Zhang; Mingshe Zhu; W Griffith Humphreys
ISBN: 9780471733133 047173313X
OCLC Number: 123962927
Description: xxi, 609 pages : illustrations ; 25 cm
Contents: Chapter 1. Overview: Drug Metabolism in the Modern Pharmaceutical Industry / Scott J. Grossman --
Chapter 2. Oxidative, Reductive, and Hydrolytic Metabolism of Drugs / F. Peter Guengerich --
Chapter 3. Conjugative Metabolism of Drugs / Rory Remmel, Swati Nagar and Upendra Argikar --
Chapter 4. Enzyme Kinetics / Timothy S. Tracy --
Chapter 5. Metabolism-Mediated Drug-Drug Interactions / Hongjian Zhang, Michael W. Sinz, and A. David Rodrigues --
Chapter 6. Drug Transporters in Drug Disposition, Drug Interactions and Drug Resistance / Cindy Q. Xia, Johnny J. Yang, and Suresh K. Balani --
Chapter 7. Regulatory Considerations of Drug Metabolism and Drug Interaction Studies / Ziaoxiong Wei and Mingshe Zhu --
Chapter 8. Drug Metabolism Research as an Integral Part of the Drug Discovery Process / W. Griffith Humphreys --
Chapter 9. Role of Drug Metabolism in Drug Development / Ramaswamy Iyer and Donglu Zhang. Chapter 10. Applications of Liquid Radiochromatography Techniques in Drug Metabolism Studies / Mingshe Zhu, Weiping Zhao, and W. Griffith Humphreys --
Chapter 11. Application of Liquid Chromatography-Mass Spectrometry for Metabolite Identification / Shuguang Ma and Swapan K. Chowdhury --
Chapter 12. Introduction to NMR and its Application to Metabolite Structure Determination / Xiaohua Huang, Robert Powers, Adrienne Tymiak, Robert Espina and Vikram Roongta --
Chapter 13. Determination of Metabolic Rates and Enzyme Kinetics / Zhi-Yi Zhang and Laurence S. Kaminsky --
Chapter 14. Protocols for Assessment of In vitro and In vivo Bioactivation Potential of Drug Candidates / Zhoupeng Zhang and Jinping Gan --
Chapter 15. Reaction Phenotyping / Susan Hurst, J. Andrew Williams and Steven Hansel --
Chapter 16. Analysis of In vitro Cytochrome P450 Inhibition in Drug Discovery and Development / Magang Shou and Renke Dai --
Chapter 17. Testing Drug Candidates for CYP3A4 Induction / Gang Luo, Liang-Shang Gan, and Thomas Guenther --
Chapter 18. ADME Studies in Animals and Humans: Experimental Design, Metabolite Profiling and Identification, and Data Presentation / Donglu Zhang and S. Nilgun Comezoglu.
Responsibility: edited by Donglu Zhang, Mingshe Zhu, W. Griffith Humphreys.
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Abstract:

Drug Metabolism in Drug Design and Development provides a practical description of what happens during the drug design and development process and focuses on issues such as: what data are needed;  Read more...

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"I highly recommend this book to anyone interested in drug metabolism." ( Journal of Medicinal Chemistry , 2008)

 
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