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Drug resistance in leishmania parasites : consequences, molecular mechanisms and possible treatments

Author: Alicia Ponte-Sucre; Maritza Padrón-Nieves
Publisher: Cham, Switzerland : Springer, 2018.
Edition/Format:   eBook : Document : English : Second editionView all editions and formats
Summary:
Providing a comprehensive review of the epidemiology and pathology of Leishmania and Leishmaniasis, this book offers a close examination of this parasitic disease and its resistance to drugs, including its molecular basis, consequences and possible treatments.
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Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Alicia Ponte-Sucre; Maritza Padrón-Nieves
ISBN: 9783319741864 3319741861 3319741853 9783319741857 9783319741871 331974187X 9783030089306 3030089304
OCLC Number: 1050163143
Notes: Includes index.
Description: 1 online resource
Contents: Leishmaniasis : the biology of a parasite --
Determinant features in leishmaniasis --
Molecular evolution and phylogeny of leishmania --
The role of reservoirs : cananie leishmaniasis --
Epidemiology of leishmaniasis in the time of drug resistance (the miltefosine era) --
The role of the immune system in resistance to infection --
Challenges in the diagnosis, treatment and control of leishmaniasis in times of drug resistance --
Co-infection with HIV --
Visceral leishmaniasis --
American tegumentary leishmaniasis --
The challenges of effective leishmaniasis treatment --
Molecular features of drug resistant leishmania --
The role of proteomics in the study of drug resistance --
The role of ABC transporters in drug-resistant leishmania --
Functional analysis of leishmania membrane (non-ABC) transporters involved in drug resistance --
Tools and strategies to circumvent drug resistance in leishmania --
Bioinformatics in leishmania drug design --
P-glycoprotein-like transportyers in leishmania : a search for reversal agents --
The concept of fitness in leishmania.
Responsibility: Alicia Ponte-Sucre, Maritza Padrón-Nieves, editors.

Abstract:

Providing a comprehensive review of the epidemiology and pathology of Leishmania and Leishmaniasis, this book offers a close examination of this parasitic disease and its resistance to drugs,  Read more...

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