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Dynamics of cholinergic function

Author: Israel Hanin
Publisher: New York : Plenum, ©1986.
Series: Advances in behavioral biology, v. 30.
Edition/Format:  Print book : Conference publication : EnglishView all editions and formats
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Genre/Form: Congress
Conference papers and proceedings
Congresses
Congrès
Additional Physical Format: Online version:
Conference on Dynamics of Cholinergic Function (1983 : Oglebay Park, W. Va.).
Dynamics of cholinergic function.
New York : Plenum, ©1986
(OCoLC)565182648
Online version:
Conference on Dynamics of Cholinergic Function (1983 : Oglebay Park, W. Va.).
Dynamics of cholinergic function.
New York : Plenum, ©1986
(OCoLC)608567318
Material Type: Conference publication
Document Type: Book
All Authors / Contributors: Israel Hanin
ISBN: 0306423847 9780306423840
OCLC Number: 14001748
Notes: "Based on the Conference on Dynamics of Cholinergic Function, held October 31-November 4, 1983, at Wilson Lodge at Oglebay Park, West Virginia"--Title page verso.
Description: xviii, 1273 pages, 5 unnumbered pages of plates : illustrations (some color) ; 26 cm.
Contents: I. Cholinergic Pathways: Anatomy of the Central Nervous System.- Cholinergic Systems in the Central Nervous System: Retrospection, Anatomic Distribution, and Functions.- Cholinergic Neurons and Cholinergic Projections in the Mammalian CNS.- Cortical Cholinergic Innervation: Distribution and Source in Monkeys.- Identification of Putative M1 Muscarinic Receptors Using [3H] Pirenzepine: Characterization of Binding and Autoradiographic Localization in Human Stellate Ganglia.- Neurotransmitters That ACT on Cholinergic Magnocellular Forebrain Nuclei Influence Cortical Acetylcholine Output.- Biochemistry and Immunocytochemistry of Choline Acetyltransferase.- Autoradiographic Localization of Subtypes of Muscarinic Agonist and Antagonist Binding Sites: Alterations Following CNS Lesions.- Immunocytochemical Evidence for the Intra-Axonal Transport of nAChR-Like Material in Motor Neurons.- Lateralization of Cholinergic and Energy Metabolism Related Enzymes in Human Temporal Cortex.- Immunological Approach to Cholinergic Transmission: Production of Monoclonal Antibodies Against Presynaptic Membranes Isolated from the Electric Organ of Torpedo Marmorata.- II. Aging, Sdat and Other Clinical Conditions.- Reduced Acetylcholine Synthesis in Alzheimer's Disease is a Clinically Relevant Change.- Cortical Cholinergic Hypofunction and Behavioral Impairment Produced by Basal Forebrain Lesions in the Rat.- Clinical Studies of the Cholinergic Deficit in Alzheimer's Disease.- Protection and Therapeutic Effect of CDP Choline in Hypocapnic Neurons in Culture.- The Aging of Cholinergic Synapses: Ontogenesis of Cholinergic Receptors.- Aging of Cholinergic synapses: Fiction or Reality?.- Interactions of Calcium Homeostasis, Acetylcholine Metabolism, Behavior and 3,4-Diaminopyridine During Aging.- Cholinergic Dysfunction and Memory: Implications for the Development of Animal Models of Aging and Dementia.- Relationships between Choline Acetyltransferase and Muscarinic Binding in Acing Rodent Brain and in Alzheimer's Disease.- Cholinergic Hypofunction and Dementia: Relation of Neuronal Loss in Different Parts of the Nucleus Basalis to Cortical Neuropathological Changes.- Basal Forebrain Cholinergic Systems in Primate Brain: Anatomical Organization and Role in the Pathology of Aging and Dementia.- Cell Counts in the Nucleus Basalis of Meynert and the Supraoptic Nucleus in Alzheimer-Diseased Brains.- Sympathetic Ingrowth: A Result of Cholinergic Nerve Injury IN the Adult Mammalian Brain.- Determinants of Acetylcholine Levels in Aged Rats.- Elevated Red Cell to Plasma Choline Ratios in Alzheimer's Disease.- Plasma and Red Blood Cell Choline in Aging: Rats, Monkeys and Man.- Human Red Blood Cell Choline in Aging and Senile Dementia: Effects of Precursor Therapy.- The USE of Positron Emission Tomography for the Evaluation of Choline Metabolism in the Brain of the Rhesus Monkey.- Cholinergic Mechanisms in Spinal Cord and Muscle.- Central Acetylcholine and Stress Induced Cardiovascular, Neuroendocrine and Behavioral Changes: Effects of Physostigmine and Neostigmine.- Muscarinic Supersensitivity of Anterior Pituitary Acth and ?-Endorphin Release in Major Depressive Illness.- Cholinergic Receptor Binding in the Frontal Cortex of Suicide Victims.- Membrane Transport of Choline by the Human Erythrocyte: Relationship to Intracellular Choline Content, and Effect of Treatment with Lithium.- Studies on the Synaptic Function in Muscle After Nerve Crush in Normal and Diabetic Rats.- Cholinergic REM Sleep Induction Response as a Marker of Endogenous Depression.- III. Cholinergic PRE- and Post-Synaptic Receptors.- Stereoselectivity of Some Muscarinic and Antimuscarinic Agents Related to Oxotremorine.- Affinity and Efficacy of oxotremorine Analogs at Ileal Muscarinic Receptors.- In Vivo and in Vitro Studies on a Muscarinic Presynaptic Antagonist and Postsynaptic Agonist: BM-5.- Interactions of Alaproclate, a Selective 5HT-Uptake Blocker, with Muscarinic Receptors: in Vivo and in Vitro Studies.- Presynaptic Muscarinic Receptors: Change of Sensitivity During Long-Term Drug Treatment.- Characterization of [3H]-Nicotine Binding in Rodent Brain and Comparison with the Binding of Other Labelled Nicotinic Ligands.- The Cholinergic Ligand Binding Material of Axonal Membranes.- Do Motor Neurons Contain Functional Prejunctional Cholinoceptors.- Pharmacological Characterization of Axonally Transported [125I]-?-Bungarotoxin Binding Sites in Rat Sciatic Nerve.- Nicotinic Cholinergic Receptors Labeled with [3H]Acetylcholine in Brain: Characterization, Localization and in Vivo Regulation.- IV. Acetylcholine Release.- Resting Release of Acetylcholine at the Motor Endplate.- Evoked Release of Acetylcholine at the Motor Endplate.- Depolarization Induced Hydrolysis of Cytoplasmic ACh in Mouse Brain.- Separation of Recycling and Cholinergic Nerve Terminals Guineapig Ileum.- Biochemical Implications of the Synaptic Vesicle Organization in Quick Frozen Electric Organ Nerve Terminals.- Presynaptic Changes Accompanying Transmission of a Single Nerve Impulse: An Interdisciplinary Approach Using Rapid Freezing.- Tentative Identification of the Choline Transporter in Cholinergic Presynaptic Plasma Membrane Preparations from Torpedo Electric Organ.- A Reconstituted Presynaptic Membrane Equipped with Protein Structures Which Permit the Calcium Dependent Release of Acetylcholine.- Storage and Secretion of Acetylcholine and Dopamine by PC12 Cells.- Effects of Exogenous Choline on Acetylcholine and Choline Contents and Release in Striatal Slices.- Acetylcholine and Choline Contents of Rat Skeletal Muscle Determined by a Radioenzymatic Microassay: Effects of Drugs.- PRE- and Postsynaptic Effects of Muscarinic Antagonists in the Isolated Guinea Pig Ileum.- Presynaptic Modulation of Acetylcholine Release.- Effect of Diisopropylfluorophosphate on Synaptic Transmission and Acetylcholine Sensitivity in Neuroblastoma-Myotube CO-Culture.- Acetylcholine and Choline Contents of Rat Skeletal Muscle Determined by a Radioenzymatic Microassay: Effects of Drugs.- Distribution of Presynaptic Receptors Modulating Acetylcholine Release.- Muscarinic Receptor Activation Increases Efflux of Choline from Isolated Heart and Rat Cortex in Vivo. Interactions with Forskolin and Ibmx.- Long Term Potentiation of Cholinergic Transmission in the Sympathetic Ganglion.- Control of the Release of [3H]-Acetylcholine from Rat Hippocampal Slices by Aminopyridines and Phencyclidine.- A Comparison between Endogenous Acetylcholine Release and [3H] Choline Outflow from Guinea-PIG Brain Slices.- Relationship between Calcium Entry and ACh Release in K+-Stimulated Rat Brain Synaptosomes.- V. Cholinesterases, Anticholinesterases and Reactivators.- Activation and Inhibition of the Nicotinic Receptor: Actions of Physostigmine, Pyridostigmine and Meproadifen.- Molecular Relationship between Acetylcholinesterase and Acetylcholine Receptors.- Acetylcholinesterase and the Maintenance of Neuromuscular Structure and Function.- Striatal Dopamine-?-Aminobutyric Acid-Acetylcholine Interaction in Organophosphate-Induced Neurotoxicity.- Polymorphism of Cholinesterase: Possible Insertion of the Various Molecular forms in Cellular Structures.- An Endogenous Neurotrophic Factor for the Maintenance of Acetylcholinesterase and Butyrylcholinesterase in the Preganglionically Denervated Superior Cervical Ganglion of the Cat.- Pharmacokinetics of [14C]-Sarin and Its Changes by Obidoxime and Pralidoxime.- Succinylcholine - A Method of Determination. Distribution and Elimination.- Cholinergic Effects of HI-6 in Soman Poisoning.- Acetylcholine Turnover in Mouse Brain: Influence of Cholinesterase Inhibitors.- Central Versus Peripheral Antagonism of Cholinesterase Inhibitor Induced Lethality.- Structural Gene Mutations Affecting Acetylcholinesterase and Choline Acetyltransferase Perturb Behavior and Development in a Simple Invertebrate.- VI. Acetylcholine Synthesis. Metabolism and Precursors.- Choline Fluxes to and from the Rat Cerebral Cortex Studied with the "Cup Technique" In Vivo.- Biochemical Effects of Lecithin Administration.- Factors Which Influence the Availability of Choline to Brain.- The Utilization of Supplemental Choline by Brain.- Effects of the Combined Treatment of Rats with Fluphenazine and Choline or Lecithin on the Striatal Cholinergic and Dopaminergic System.- Mechanisms of Acetylcholine Synthesis: Coupling with Choline Transport.- Target Tissue Influences on Cholinergic Development of Parasympathetic Motor Neurons.- Inhibition of Acetylcholine Synthesis in Vitro.- The Role of Glial Cells in Neuronal Acetylcholine Synthesis.- The Efflux of Choline from Nerve Cells: Mediation by Ionic Gradients and Functional Exchange of Choline from Glia to Neurons.- Choline Uptake in the Hippocampus: Inhibition of Septalhippocampal Cholinergic Neurons by Intraventricular Barbiturates.- VII. Second Messenger Mechanisms.- Studies on a cAMP-Dependent Protein Kinase Obtained from Nicotinic Receptor-Bearing Microsacs.- Differential Effects of Carbachol and Oxotremorine on Muscarinic Receptors, Cyclic AMP Formation, and Phosphoinositide Turnover in Chick Heart Cells.- Polyphosphoinositide and Phosphoprotein Responses to Muscarinic Receptor Activation in Bovine Adrenal Medulla.- VIII. Interaction of Acetylcholine with Other Neurotransmitter Systems.- GABAA VS. GABAB Modulation of Septal-Hippocampal Interconnections.- Septal Gabaergic Neurons: Localization and Possible Involvement in the Septal-Hippocampal Feedback Loop.- Regulation of Drugs Affecting Striatal Cholinergic Activity by Corticostriatal Projections.- Excitatory Amino Acid Influence on Striatal Cholinergic Transmission.- Contribution of the Dorsal Noradrenergic Bundle to the Effect of Amphetamine on Acetylcholine Turnover.- Substantia Innominata - Cortical Cholinergic Pathway: Regulatory Afferents.- Enkephalinergic Modulation of Cholinergic Transmission in Parasympathetic Ganglia of the Cat Urinary Bladder.- Vasoactive Intestinal Polypeptide-Muscarinic Cholinergic Interactions.- Serotonin and a Role in the Modulation of Cholinergic Transmission in the Mammalian Prevertebral Ganglia.- Cholinergic and Peptidergic Regulation of Ganglionic Tyrosine Hydroxylase Activity.- Regulation of Acetylcholine Release From Rodent Cerebrum by Presynaptic Receptors, Methionine Enkephalin and Substance P.- Selective Facilitatory Effects of Vasoactive Intestinal Polypeptide on Muscarinic Mechanisms in Sympathetic and Parasympathetic Ganglia of the Cat.- Interaction of Cyclic AMP with Muscarinic Autoinhibition of [3H]-Acetylcholine Secretion in Guinea-Pig Ileum Myenteric Plexus.- IX. Cholinergic Mechanisms in Physiological Function, Including Cardiovascular Events.- Parasympathetic Innervation of the Heart: Acetylcholine Turnover in Vivo.- Tendency for Repetitive Vagal Activity to Synchronize Cardiac Pacemaker Cells.- Transient Inotropic and Dromotropic Responses to Brief Vagal Stimuli.- Brain Acetylcholine in Hypertension and Behavior: Studies Using N- (4-Diethylamino-2-Butynyl)-Succinimide.- Inhibition of Brain Acetylcholine Biosynthesis by Clonidine and Methyldopa: Relevance to Hypertensive Disease.- Acetylcholine - Prostanoid Interaction in the Pulmonary Circulation.- X. Neurotoxic Agents and False Transmitters.- Long-Term Effects of AF64A on Learning and Memory Processes in the Rat.- Biochemical and Behavioral Effects of Ethylcholine Mustard Aziridinium Ion.- Histochemical and Biochemical Effects of the Injection of AF64A Into the Nucleus Basalis of Meynert: Relevance to Animal Models of Senile Dementia of the Alzheimer Type.- Neurotoxic Effects of Nitrogen Mustard Analogues of Choline.- Synthesis, Storage and Release of Choline Analog Esters.- A New Pharmacological Tool to Study Acetylcholine Storage in Nerve Terminals.- Alkylating Derivatives of Oxotremorine Have Irreversible Actions on Muscarinic Receptors.- Action of Phospholipase Neurotoxins on Torpedo Synaptosomes: Changes in Membrane Potential and Phosphoglyceride Composition.- Studies of Two Novel Presynaptic Toxins.- XI. Conference on Dynamics of Cholinergic Function: Overview and Comments.
Series Title: Advances in behavioral biology, v. 30.
Responsibility: edited by Israel Hanin.

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