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Efficacy of Antidepressant Treatment for Inpatients with Severe Depression

Author: Marlijn Vermeiden
Publisher: Erasmus University Rotterdam 2018-06-08
Edition/Format: Book Book : English
Summary:
textabstractThe main aim of this thesis was to evaluate the efficacy of three phases of a treatment algorithm of inpatients with severe depression: phase I optimal antidepressant monotherapy (plasma level targeted dose imipramine or high-dose (375 mg/day) venlafaxine); phase II subsequent lithium addition in case of insufficient improvement of antidepressant monotherapy; phase Ill subsequent ECT in case of  Read more...
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Details

Document Type: Book
All Authors / Contributors: Marlijn Vermeiden
ISBN: 978-94-6299-894-0
Language Note: English
Unique Identifier: 8086657111
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Abstract:

textabstractThe main aim of this thesis was to evaluate the efficacy of three phases of a treatment algorithm of inpatients with severe depression: phase I optimal antidepressant monotherapy (plasma level targeted dose imipramine or high-dose (375 mg/day) venlafaxine); phase II subsequent lithium addition in case of insufficient improvement of antidepressant monotherapy; phase Ill subsequent ECT in case of insufficient improvement of antidepressant-lithium treatment. Additionally, this thesis aims to further investigate predictors of antidepressant treatment response, i.e. early drug response, gender and menopausal status.

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