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Endothelium-dependent hyperpolarizations

Author: Paul M Vanhoutte
Publisher: Amsterdam : Harwood Academic Publishers, ©1999.
Edition/Format:   Print book : Conference publication : EnglishView all editions and formats

This further volume reinforces the concept that endothelium-derived hyperpolarizing factor (EDHF), as opposed to nitric oxide (NO), is of particular importance in smaller blood vessels, and it  Read more...


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Genre/Form: Conference papers and proceedings
Material Type: Conference publication
Document Type: Book
All Authors / Contributors: Paul M Vanhoutte
ISBN: 9789057024924 9057024926
OCLC Number: 41387872
Notes: Proceedings of the Second International Symposium on Endothelium-Derived Hyperpolarizing Factor, held June 5-6, 1998 in Vaux de Cernay, France.
Description: xxv, 436 pages : illustrations ; 25 cm
Contents: Endothelium-dependent hyperpolarization cannot be explained by electrical coupling between the endothelial and the smooth cells in muscular arteries; epoxyeicosatrienoic acids as endothelium-derived hyperpolarization factors in coronary arteries - potassium channel activation through endogenous ADP - ribosylation of Gs; phospholipid-derived epoxyeicosatrienoic acids mediate the relaxation's attributed to endothelium-derived hyperpolarizing factor; hyperpolarizing factors and membrane potential in cerebral arterioles - a role for astrocytes and cytochrome P450 genes; K+ is an endothelium-derived hyperpolarizing factor - an alternative working hypothesis; hyperpolarization and relaxation of vascular smooth muscle to endothelium-derived nitric oxide; endothelium-dependent responses in endothelial nitric oxide synthase knockout mice - contribution of NO, EDHF and products of cyclooxygenases; SR141716A does not inhibit non-nitric oxide, non-prostanoid mediated relaxations to ethanol and cyclopiazonic acid in the isolated porcine pulmonary artery; cannabinoid receptors are present in arterial smooth muscle, are coupled to the inhibition of adenylate cyclase, but are not involved in vasorelaxation; potassium channels involved in hyperpolarization and relaxation induced by endothelium-derived hyperpolarizing factor in rat mesenteric arteries; the role of nonselective cation current in regulation of membrane potential in vascular smooth muscle cells; diminished cyclic GMP - and hyperpolarization-dependent ralaxation's to acetylcholine in rabbit carotid arteries with a neointima; contribution of nitric oxide and endothelium-derived hyperpolarizing factor to the relaxation evoked by bradykinin in porcine coronary arteries four weeks after removal of the endothelium; role of endothelium-derived hyperpolarizing factor in relaxation of pregnant rat uterine artery by corticotrophin-releasing factor; endothelium-derived hyperpolarizing factor in omental arteries from normotensive pregnant women; mechanisms of vasodilation in human conduit arteries; vasodilation to bradykinin in mediated by an endothelium-derived hyperpolarizing factor essential in hypertensive patients; importance of endothelium-derived hyperpolarizing factor in human arteries.
Responsibility: edited by Paul M. Vanhoutte.


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