Find a copy online
Links to this item
Find a copy in the library
Finding libraries that hold this item...
Details
Genre/Form: | Thèses et écrits académiques |
---|---|
Material Type: | Document, Thesis/dissertation, Internet resource |
Document Type: | Internet Resource, Computer File |
All Authors / Contributors: |
Camille Legros; Daniel Taton, chimie des mateÌriaux).; Michael Kam Chiu Tam; Marie-Claire Gillet-De Paw; Sébastien Lecommandoux; Stéphane Carlotti; Catherine Amiel, chercheuse en chimie).; Richard Hoogenboom; Université de Bordeaux (2014-....).; University of Waterloo (Canada).; École doctorale des sciences chimiques (Talence, Gironde).; Université de Liège.; Laboratoire de Chimie des Polymères Organiques (Bordeaux).; Université Bordeaux-I (1971-2013). |
OCLC Number: | 906011417 |
Notes: | Thèse soutenue en co-tutelle. Titre provenant de l'écran-titre. |
Description: | 1 online resource |
Responsibility: | Camille Legros ; sous la direction de Daniel Taton et de Michael Kam Chiu Tam et de Marie-Claire Gillet-De Paw et de Sébastien Lecommandoux. |
Abstract:
This PhD work is based on the design of poly(2-oxazoline) (POx)hydrogels and nanogels, by chemical or physical cross-linking, aimed to be used for biomedical applications. Nanogels were first prepared in dilute media and in inverse emulsion based on a statistical copolymer made of 2-ethyl-2-oxazoline and ethyleneimine units. These stimuli-responsive nanogels were swelling in acidic media and were cleaved in reductive environment. They proved to be non-cytotoxic and act as protein repellent. Second, a reactive platform based on a statistical POx polymerbearing aldehyde functionalities was engineered, enabling the synthesis of graft and cross-linked POx. Last, a block copolymer made of 2-methyl- and 2-isopropyl-2-oxazoline units, proved to self-assemble into micelles when heated above its LCST,for a short period of time (< 1h30). When annealed for a longer time (> 1h30),crystallization-driven self-assembly led to the formation of different morphologies(fiber rods and cross-linked micelles).
Reviews

