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Genre/Form: | Thèses et écrits académiques |
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Material Type: | Thesis/dissertation |
Document Type: | Book |
All Authors / Contributors: |
Gaël Genet; Céline Galès; Université Toulouse 3 Paul Sabatier (1969-....). |
OCLC Number: | 889560016 |
Description: | 1 vol. (286 p.) : ill. en coul. ; 30 cm. |
Responsibility: | Gaël Genet ; directeur de thèse, Céline Galés. |
Abstract:
Ephrin-B1 is expressed at the lateral membrane (ML) of the cardiomyocyte (CM). Its deletion (KO General and targeted in CMs) causes an architectural disorganization of the heart tissue, correlated with a loss of the rode shape of CMs and ultrastructure of the ML. These animals show hypersensitivity to barometric stress characterized by high mortality and exacerbation of tissue disorganization. In a model of heart failure (HF), gene expression of ephrin - B1dans CMs is reduced by 50 %. This work suggests that Ephrine-B1, stabilizing the structure of the ML and morphology of CM could be a new player involved in the development of the HF. Using atomic force microscopy we have shown that in healthy mice, the surface of the CM has a periodic architecture hollow / crests, peaks are correlated to the presence of subsarcolemmal mitochondria (SSM). The CMs of mice with ischemic post HF have a general disorganization of the surface topography of the sarcolemma characterized by a loss of hollow / crests frequency. These changes are associated with death SSM, reporting CM smooth surfaces. Osmotic stress ( formamide ) indicates that the death of SSM before the breakdown of T - tubules . The death of SSM could therefore represent an initiating event of changes to the HF. The study of the ephrin -B1 role in structuring the sarcolemma thus opens a new research and raises the importance of alterations in the ML of CMs in the development of the HF.
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