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E-mail Message: I thought you might be interested in this item at http://www.worldcat.org/oclc/732603730 Title: Epidermal growth factor receptor mutation (EGFR) testing for prediction of response to EGFR-targeting tyrosine kinase inhibitor (TKI) drugs in patients with advanced non-small-cell lung cancer : an evidence-based analysis Publisher: Toronto, Ont. : Medical Advisory Secretariat, Ontario Ministry of Health and Long-Term Care, 2010 ISBN/ISSN: 9781443548298 1443548294 OCLC:732603730

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Epidermal growth factor receptor mutation (EGFR) testing for prediction of response to EGFR-targeting tyrosine kinase inhibitor (TKI) drugs in patients with advanced non-small-cell lung cancer : an evidence-based analysis

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Epidermal growth factor receptor mutation (EGFR) testing for prediction of response to EGFR-targeting tyrosine kinase inhibitor (TKI) drugs in patients with advanced non-small-cell lung cancer : an evidence-based analysis

Author:	Ontario. Ministry of Health and Long-Term Care. Medical Advisory Secretariat.
Publisher:	Toronto, Ont. : Medical Advisory Secretariat, Ontario Ministry of Health and Long-Term Care, 2010
Series:	Ontario health technology assessment series, v. 10, no. 24.
Edition/Format:	eBook : Document : State or province government publication : English
Database:	WorldCat
Rating:	(not yet rated) 0 with reviews - Be the first.
Subjects	Epidermal growth factor -- Receptors -- Testing -- Cost effectiveness. Epidermal growth factor -- Receptors -- Testing. Lungs -- Cancer -- Chemotherapy. View all subjects
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Material Type:	Document, Government publication, State or province government publication, Internet resource
Document Type:	Internet Resource, Computer File
All Authors / Contributors:	Ontario. Ministry of Health and Long-Term Care. Medical Advisory Secretariat.
ISBN:	9781443548298 1443548294
OCLC Number:	732603730
Description:	1 online resource (48 pages).
Contents:	Executive summary. Objective -- Clinical Need: Target Population and Condition -- The Technology: EGFR mutation testing -- Research Questions -- Methods -- Outcomes of Interest -- Quality of Evidence -- Summary of Findings -- Conclusions. Appendix 1, Literature search strategies -- Appendix 2, Grade of evidence -- References. Background. Objective -- Clinical Need and Target Population: Non-Small Cell Lung Cancer; Treatment in Patients with Advanced Non-small Cell Lung Cancer -- Predictive Biomarkers of Response to EGFR-Targeted TKI Drugs in NSCLC -- 1. EGFR Protein Overexpression: 1.1 EGFR Protein Overexpression Testing; 1.2 Effectiveness of EGFR Overexpression in predicting response to TKIs -- 2. EGFR gene copy number or dosage: 2.1 EGFR Amplification Testing; 2.2 Effectiveness of EGFR Amplification in Predicting Response to TKIs -- 3. EGFR gene somatic mutations: 3.1 EGFR gene mutation testing; 3.2 EGFR somatic mutations and response to TKIs -- Ontario Context. Economic analysis. Study Question -- Economic Analysis Overview -- Economic Literature Review -- Target Population -- Perspective -- Comparators -- Time Horizon -- Discounting -- Model Structure -- Outcomes -- Resource Use and Costs -- Probabilities and Utilities -- Sensitivity Analysis -- Results and Discussion -- Supplementary Analysis -- Budget Impact Analysis -- Economic Analysis Conclusion. Evidence-based analysis. Key Questions -- Research Methods: Literature Search; Search Strategy; Inclusion Criteria; Exclusion Criteria; Outcomes of Interest -- Quality of Evidence. Results of evidence-based analysis. Literature Search: Fig 1, Flow Diagram of the Systematic Literature Search -- Section 1. Published Systematic Evidence Reviews -- Section 2. MAS Evidence Review: 2.1 Clinical Effectiveness of EGFR Mutation testing in the First-Line Setting; 2.2 Clinical Effectiveness of EGFR Mutation testing in the Second- or Third-Line Setting.
Series Title:	Ontario health technology assessment series, v. 10, no. 24.
Other Titles:	EGFR genetic testing and non-small-cell lung cancer
Responsibility:	Medical Advisory Secretariat.
More information:	Cover image:

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