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Epigenetics, nuclear organization and gene function : with implications of epigenetic regulation and genetic architecture for human development and health

Author: John C Lucchesi
Publisher: Oxford, United Kingdom : Oxford University Press, 2019. ©2019
Edition/Format:   Print book : English : First editionView all editions and formats
Summary:

Provides a framework to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. It further aims to highlight  Read more...

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Document Type: Book
All Authors / Contributors: John C Lucchesi
ISBN: 9780198831204 019883120X 9780198831211 0198831218
OCLC Number: 1037624583
Description: xviii, 286 pages : illustrations ; 25 cm
Contents: Epigenetic phenomena in fungi, plants and animals --
The basic structure of chromatin --
The basic mechanism of gene transcription --
Chromatin modification and remodeling --
Epigenetic chromatin changes and the transcription cycle --
The role of non-coding RNAs --
Maintenance of the active and inactive states --
DNA methylation and gene expression --
Regulation of domains and whole chromosomes --
Architectural organization of the genome --
The nuclear envelope --
The nucleolus --
Nuclear bodies --
Chromatin replication --
DNA repair and genomic stability --
Inheritance of chromatin modifications through the cell cycle --
Stem cells --
Nuclear reprogramming and induced pluripotency --
Transgenerational inheritance of epigenetic traits --
Aging, cellular senescence and cancer : the role of genomic instability, cellular homeostasis and telomeres --
Aging, cellular senescence and cancer : epigenetic alterations and nuclear remodeling --
Developmental systems and their dysfunction.
Responsibility: John C. Lucchesi.

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