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Epithelial-mesenchymal interactions in the developing lung.
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Epithelial-mesenchymal interactions in the developing lung.

Author: JM Shannon Affiliation: Division of Pulmonary Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. john.shannon@chmcc.org; BA Hyatt
Edition/Format: Article Article : English
Publication:Annual review of physiology, 2004; 66: 625-45
Other Databases: WorldCatWorldCat
Summary:
Classical experiments in embryology have shown that normal growth, morphogenetic patterning, and cellular differentiation in the developing lung depend on interactive signaling between the endodermal epithelium and mesenchyme derived from splanchnic mesoderm. These interactions are mediated by a myriad of diffusible factors that are precisely regulated in their temporal and spatial expression. In this review we  Read more...
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Details

Document Type: Article
All Authors / Contributors: JM Shannon Affiliation: Division of Pulmonary Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. john.shannon@chmcc.org; BA Hyatt
ISSN:0066-4278
Language Note: English
Unique Identifier: 112065437
Awards:

Abstract:

Classical experiments in embryology have shown that normal growth, morphogenetic patterning, and cellular differentiation in the developing lung depend on interactive signaling between the endodermal epithelium and mesenchyme derived from splanchnic mesoderm. These interactions are mediated by a myriad of diffusible factors that are precisely regulated in their temporal and spatial expression. In this review we first describe factors regulating formation of the embryonic foregut. We then discuss the experiments demonstrating the importance of tissue interactions in lung patterning and differentiation. Finally, we detail the roles that a few key signaling systems-fibroblast growth factors and their receptors, sonic hedgehog and Gli genes, Wnt genes and beta-catenin, and BMP4-play as mediators of epithelial-mesenchymal interactions in the developing lung.

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