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Le travail décrit dans cette thèse concerne la synthèse et l'étude de la réactivité d'acides et d'esters boroniques en série pyrazole. La première partie est consacrée à l'étude bibliographique des différentes méthodes de synthèse d'acides et d'esters boroniques notamment en série hétérocyclique azotée ainsi qu'à l'étude de la synthèse et de la réactivité du pyrazole.La seconde partie expose les travaux personnels concernant les méthodes de synthèse d'acides et d'esters pyrazolylboroniques via une réaction de lithiation. L'expérience acquise dans ce domaine a été mise à profit dans la synthèse de 3(5)-halogéno-1H-pyrazoles. L'étude de la réactivité des dérivés pyrazolylboroniques, notamment dans des couplages métallo-catalysés, nous a conduits à préparer des diarylpyrazoles et de nouvelles pyrazoloisoindolones. Enfin les premiers résultats concernant les synthèses de dérivés organoborés en séries triazoles et tétrazole sont présentés.La partie expérimentale de ce document décrit les modes opératoires et les caractéristiques physicochimiques des composés présentés.Enfin, plus de 200 références bibliographiques replacent cette étude dans son contexte chimique et pharmacologique

Etude de la synthèse et de la réactivité d'acides et d'esters boroniques en série pyrazole