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Genre/Form: | Thèses et écrits académiques |
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Material Type: | Thesis/dissertation |
Document Type: | Book |
All Authors / Contributors: |
Anne-Laure Gérard; Sylvain Rault; Université de Caen Normandie.; Université de Caen. UFR des sciences pharmaceutiques. |
OCLC Number: | 799687874 |
Description: | 1 vol. (294 p.) : ill. ; 30cm. |
Responsibility: | Anne-Laure Gérard ; [sous la direction de] Sylvain Rault. |
Abstract:
The work described in this thesis relates to the study of the synthesis and the reactivity of boronic acids and esters in pyrazole series. The first part is devoted to the bibliographical study of the various synthetic methods of organoboron compounds and particularly in nitrogen containing heterocyclic series and the study of the synthesis and the reactivity of pyrazole.The second part details personnal work concerning the synthetic methods of pyrazolylboronic acids and esters via lithiation reaction. The experience gained in this field was made profitable in the synthesis of 3(5)-halogeno-1H-pyrazoles. The study of the reactivity of pyrazolylboronic compounds, in particular in cross-coupling reaction, led us to prepare diarylpyrazoles and new pyrazoloisoindolones. Finally our first results concerning the syntheses of organoboron compounds in triazoles and tetrazole series are presented.The experimental part of this document describes the procedures and the physicochemical characteristics of the compounds presented.Finally more than 200 bibliographical references replace this study in its chemical and biological context.
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