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Étude de l'extraction sélective par des procédés innovants de peptides issus de la protéolyse enzymatique de l'hémoglobine bovine

Author: Mathieu Vanhoute; Didier Guillochon; Pascal Dhulster; Université Lille 1 - Sciences et technologies (Villeneuve-d'Ascq / 1970-2017).
Publisher: 2010.
Dissertation: Thèse de doctorat : Ingénierie des fonctions biologiques : Lille 1 : 2010.
Edition/Format:   Computer file : Document : Thesis/dissertation : FrenchView all editions and formats
Summary:
Trois procédés innovants ont permis d'extraire sélectivement des peptides actifs d'un hydrolysat complexe issu de la protéolyse pepsique de l'hémoglobine bovine. Un premier procédé d'extraction biphasique assistée par des alkyl-sulfonates a permis de modifier l'affinité des peptides pour la phase organique par la formation de paires d'ions. Ces études des conditions d'extraction de peptides opioïdes
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Genre/Form: Thèses et écrits académiques
Material Type: Document, Thesis/dissertation, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Mathieu Vanhoute; Didier Guillochon; Pascal Dhulster; Université Lille 1 - Sciences et technologies (Villeneuve-d'Ascq / 1970-2017).
OCLC Number: 800711094
Notes: Thèse soutenue sur un ensemble de travaux.
Titre provenant de l'écran-titre.
Description: 1 online resource
Contents: Ion-pairing separation of bioactive peptides using an aqueous/octan-1-ol micro-extraction system from bovine haemoglobin complex hydrolysates / Vanhoute, Mathieu, Froidevaux, Renato, Vanvlassenbroeck, Aurelien, Lecouturier, Didier, Dhulster, Pascal, Guillochon, Didier. --
Journal of Chromatography B, 2009. --
Advancement of foam separation of bioactive peptides using an aeration column with a bubbling-draining method / Vanhoute, M., Froidevaux, R., Pierlot, C., Krier, F., Aubry, J.M., Guillochon, D.. --
Separation and Purification Technology, 2008. --
Effect of haem on the fractionation of bovine haemoglobin peptic hydrolysate by electrodialysis with ultrafiltration membranes / Vanhoute, M., Firdaous, L., Bazinet, L., Froidevaux, R., Lecouturier, D., Guillochon, D., Dhulster, P.. --
Journal of Membrane Science, 2010.
Responsibility: Mathieu Vanhoute ; sous la direction de Didier Guillochon et de Pascal Dhulster.

Abstract:

Trois procédés innovants ont permis d'extraire sélectivement des peptides actifs d'un hydrolysat complexe issu de la protéolyse pepsique de l'hémoglobine bovine. Un premier procédé d'extraction biphasique assistée par des alkyl-sulfonates a permis de modifier l'affinité des peptides pour la phase organique par la formation de paires d'ions. Ces études des conditions d'extraction de peptides opioïdes hydrophobes ont permis la mise en œuvre d'un système d'extraction dans l'octan-1-ol supporté par un contacteur à membrane. Dans un deuxième temps, un procédé de moussage-drainage fut développé sur les propriétés tensioactives des peptides et a permis de fractionner la population peptidique pour isoler une fraction aux propriétés antibactériennes. L'optimisation par plans d'expériences a mis en avant l'influence de quatre paramètres majeurs (concentrations en hydrolysat et en sel, pH des solutions d'hydrolysat et de drainage) et a permis de multiplier par 3,4 l'enrichissement de cette fraction dans la solution récoltée. Enfin un procédé récemment développé, l'électrodialyse associée à des membranes d'ultrafiltration ayant pour seule force motrice la différence de potentiel électrique, a permis d'isoler une fraction peptidique cationique. L'étude du comportement en encrassement a révélé l'existence de phénomènes de répulsion de charges empêchant la récolte d'une fraction peptidique anionique et la formation d'agrégats hème-peptides colmatant de manière partiellement réversible les membranes d'ultrafiltration.

Three innovative processes allowed to extract selectively active peptides from a complex hydrolysate from the pepsic proteolysis of bovine haemoglobin. A first process of biphasic extraction assisted by alkyl-sulfonates allowed to modify the affinity of peptides for the organic phase by the formation of ion-pairs. These studies of conditions of extraction of opioid hydrophobe peptides allowed the implementation of a system of extraction in octan-1-ol supported by a membrane contactor. Secondly, a process of bubbling-draining was developed based on the surface tension properties of the peptides and allowed to split the peptidic population to isolate a fraction showing antibacterial properties. The optimization by experimental design advanced the influence of four major parameters (concentrations of hydrolysate and KCl, pH of solutions of hydrolysate and drainage) and allowed to multiply by 3,4 the enrichment of this fraction in the collected solution. Finally a process recently developed, the electrodialysis associated with ultrafiltration membranes having for only driving strength the difference of electric potential, allowed to isolate a cationic peptidic fraction. The study of the behavior in fouling revealed the existence of phenomena of charge repulsion preventing the isolation of a anionic peptidic fraction and the formation of aggregates haem-peptides fouling in a partially reversible way the ultrafiltration membranes.

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<http:\/\/www.worldcat.org\/oclc\/800711094<\/a>> # \u00C9tude de l\'extraction s\u00E9lective par des proc\u00E9d\u00E9s innovants de peptides issus de la prot\u00E9olyse enzymatique de l\'h\u00E9moglobine bovine<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nbgn:Thesis<\/a>, schema:MediaObject<\/a>, schema:CreativeWork<\/a>, bgn:ComputerFile<\/a> ;\u00A0\u00A0\u00A0\nbgn:inSupportOf<\/a> \"Th\u00E8se de doctorat : Ing\u00E9nierie des fonctions biologiques : Lille 1 : 2010.<\/span>\" ;\u00A0\u00A0\u00A0\nlibrary:oclcnum<\/a> \"800711094<\/span>\" ;\u00A0\u00A0\u00A0\nlibrary:placeOfPublication<\/a> <http:\/\/id.loc.gov\/vocabulary\/countries\/fr<\/a>> ;\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/2045095336#Topic\/peptides_separation<\/a>> ; # Peptides--S\u00E9paration<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/2045095336#Topic\/hemorphines<\/a>> ; # H\u00E9morphines<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/2045095336#Topic\/ultrafiltration<\/a>> ; # Ultrafiltration<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/2045095336#Topic\/hydrolysats_de_proteines<\/a>> ; # Hydrolysats de prot\u00E9ines<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/2045095336#Topic\/surfactants_biologiques<\/a>> ; # Surfactants biologiques<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/2045095336#Topic\/electrodialyse<\/a>> ; # \u00C9lectrodialyse<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/2045095336#Topic\/extraction_par_solvant<\/a>> ; # Extraction par solvant<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/2045095336#Topic\/antibiotiques_peptidiques<\/a>> ; # Antibiotiques peptidiques<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/2045095336#Thing\/moussage_drainage<\/a>> ; # Moussage-drainage<\/span>\n\u00A0\u00A0\u00A0\nschema:author<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/2045095336#Person\/vanhoute_mathieu_1982<\/a>> ; # Mathieu Vanhoute<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/2045095336#Organization\/universite_lille_1_sciences_et_technologies_villeneuve_d_ascq_1970_2017<\/a>> ; # Universit\u00E9 Lille 1 - Sciences et technologies (Villeneuve-d\'Ascq \/ 1970-2017).<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/2045095336#Person\/guillochon_didier_1948_2014<\/a>> ; # Didier Guillochon<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/2045095336#Person\/dhulster_pascal_19<\/a>> ; # Pascal Dhulster<\/span>\n\u00A0\u00A0\u00A0\nschema:datePublished<\/a> \"2010<\/span>\" ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"Ion-pairing separation of bioactive peptides using an aqueous\/octan-1-ol micro-extraction system from bovine haemoglobin complex hydrolysates \/ Vanhoute, Mathieu, Froidevaux, Renato, Vanvlassenbroeck, Aurelien, Lecouturier, Didier, Dhulster, Pascal, Guillochon, Didier. -- Journal of Chromatography B, 2009. -- Advancement of foam separation of bioactive peptides using an aeration column with a bubbling-draining method \/ Vanhoute, M., Froidevaux, R., Pierlot, C., Krier, F., Aubry, J.M., Guillochon, D.. -- Separation and Purification Technology, 2008. -- Effect of haem on the fractionation of bovine haemoglobin peptic hydrolysate by electrodialysis with ultrafiltration membranes \/ Vanhoute, M., Firdaous, L., Bazinet, L., Froidevaux, R., Lecouturier, D., Guillochon, D., Dhulster, P.. -- Journal of Membrane Science, 2010.<\/span>\"@fr<\/a> ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"Trois proc\u00E9d\u00E9s innovants ont permis d\'extraire s\u00E9lectivement des peptides actifs d\'un hydrolysat complexe issu de la prot\u00E9olyse pepsique de l\'h\u00E9moglobine bovine. Un premier proc\u00E9d\u00E9 d\'extraction biphasique assist\u00E9e par des alkyl-sulfonates a permis de modifier l\'affinit\u00E9 des peptides pour la phase organique par la formation de paires d\'ions. Ces \u00E9tudes des conditions d\'extraction de peptides opio\u00EFdes hydrophobes ont permis la mise en \u0153uvre d\'un syst\u00E8me d\'extraction dans l\'octan-1-ol support\u00E9 par un contacteur \u00E0 membrane. Dans un deuxi\u00E8me temps, un proc\u00E9d\u00E9 de moussage-drainage fut d\u00E9velopp\u00E9 sur les propri\u00E9t\u00E9s tensioactives des peptides et a permis de fractionner la population peptidique pour isoler une fraction aux propri\u00E9t\u00E9s antibact\u00E9riennes. L\'optimisation par plans d\'exp\u00E9riences a mis en avant l\'influence de quatre param\u00E8tres majeurs (concentrations en hydrolysat et en sel, pH des solutions d\'hydrolysat et de drainage) et a permis de multiplier par 3,4 l\'enrichissement de cette fraction dans la solution r\u00E9colt\u00E9e. 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