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Etude des propriétés anti-tumorales in vitro de stilbènes issus de suspension cellulaire de vigne (Vitis labrusca)

Author: Laetitia NivelleMichel Tarpin, biologiste).Laurent MartinyClaire Rossi, biologiste).Valérie Schini-KerthAll authors
Publisher: 2017.
Dissertation: Thèse de doctorat : Biochimie et biologie moléculaire : Reims : 2017.
Edition/Format:   Computer file : Document : Thesis/dissertation : French
Summary:
Le resvératrol, stilbène produit naturellement dans les grappes de raisin, possède un pouvoir anti-tumoral caractérisé par ses effets pléïotropiques. La molécule s'est ainsi montrée capable d'inhiber la cancérogenèse en agissant à de multiples niveaux. Son incidence sur la croissance tumorale in vitro est généralement associée à une perturbation dans le cycle cellulaire et à une induction
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Genre/Form: Thèses et écrits académiques
Material Type: Document, Thesis/dissertation, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Laetitia Nivelle; Michel Tarpin, biologiste).; Laurent Martiny; Claire Rossi, biologiste).; Valérie Schini-Kerth; Dominique Delmas; Virginie Aires; Université de Reims Champagne-Ardenne.; Ecole doctorale Sciences, technologies, santé (Reims, Marne).
OCLC Number: 1028748766
Notes: Titre provenant de l'écran-titre.
Description: 1 online resource
Responsibility: Laetitia Nivelle ; sous la direction de Michel Tarpin.

Abstract:

Le resvératrol, stilbène produit naturellement dans les grappes de raisin, possède un pouvoir anti-tumoral caractérisé par ses effets pléïotropiques. La molécule s'est ainsi montrée capable d'inhiber la cancérogenèse en agissant à de multiples niveaux. Son incidence sur la croissance tumorale in vitro est généralement associée à une perturbation dans le cycle cellulaire et à une induction d'apoptose. De nombreuses molécules dérivées du resvératrol se sont montrées également efficaces pour moduler la croissance tumorale. Nous avons entrepris au cours de ces travaux de thèse d'étudier les activités biologiques de stilbènes issus d'une production de culture cellulaire de vigne. Les résultats de cette étude mettent en évidence une réduction de la croissance tumorale, dans un modèle d'étude in vitro de mélanome humain, pour le resvératrol et quatre oligomères de resvératrol bioproduits. L'étude plus approfondie de trois oligomères de resvératrol a permis de révéler des différences notables par rapport entre les effets du resvératrol et ses dérivés. En effet, bien que l'inhibition de la viabilité cellulaire des lignées cancéreuses s'accompagne d'une perturbation du cycle cellulaire pour le resvératrol et ses dérivés, elle se traduit différemment selon les composés. L'action du resvératrol sur le cycle cellulaire conduit à une nette augmentation des cellules en phase S, tandis que les oligomères de resvératrol n'induisent pas d'accumulation cellulaire franche dans une phase du cycle. De plus les oligomères de resvératrol présentent des capacités anti-invasives et anti-migratoires qui ne sont pas retrouvées chez le resvératrol. Enfin l'étude sur des fibroblastes normaux d'adultes (FNA) souligne que les dérivés du resvératrol diminuent la viabilité de cellules normales et cancéreuses à des concentrations similaires contrairement au resvératrol dont l'action est nettement inférieure sur les cellules saines. Cependant le pouvoir cytotoxique du resvératrol et de ses dérivés reste beaucoup plus faible chez les cellules normales.

Resveratrol, a natural stilbene found in the grapevine, exhibits pleiotropic antitumor activities. This molecule has been shown to inhibit the cancerogenesis processes at different levels. Its impact in tumor growth, in vitro, is generally associate with a disruption in cell cycle and an apoptosis induction. Various resveratrol derivatives appear also efficient to modulate tumor growth. We have studied, during this work, biological activities of stilbenes produced by grapevine cell cutures. Our results show a decrease in melanoma human growth, in vitro, for bioproduced resveratrol oligomers as well as resveratrol itself. Our experiments underline distinct effects between resveratrol and its derivatives. Indeed, all compounds disrupt cell cycle, but resveratrol induces S-phase arrest while resveratrol oligomers failed to induce a clearly phase arrest. Moreover, only resveratrol oligomers only have the ability to counteract invasive and migratory properties of melanoma cells. Finally, experiments performed in normal human fibroblasts study show that resveratrol oligomers present a similar potential to reduce viability of cancer as well as normal cells contrary to resveratrol which is less efficient in normal cells. However the cytotoxicity of resveratrol and its derivatives is significantly reduced on normal cells.

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\n\n

Primary Entity<\/h3>\n
<http:\/\/www.worldcat.org\/oclc\/1028748766<\/a>> # Etude des propri\u00E9t\u00E9s anti-tumorales in vitro de stilb\u00E8nes issus de suspension cellulaire de vigne (Vitis labrusca)<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nbgn:Thesis<\/a>, schema:CreativeWork<\/a>, bgn:ComputerFile<\/a>, schema:MediaObject<\/a> ;\u00A0\u00A0\u00A0\nbgn:inSupportOf<\/a> \"Th\u00E8se de doctorat : Biochimie et biologie mol\u00E9culaire : Reims : 2017.<\/span>\" ;\u00A0\u00A0\u00A0\nlibrary:oclcnum<\/a> \"1028748766<\/span>\" ;\u00A0\u00A0\u00A0\nlibrary:placeOfPublication<\/a> <http:\/\/id.loc.gov\/vocabulary\/countries\/fr<\/a>> ;\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Thing\/croissance_tumorale<\/a>> ; # Croissance tumorale<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Thing\/oligomeres_de_reveratrol<\/a>> ; # Oligom\u00E8res de rev\u00E9ratrol<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Topic\/melanome<\/a>> ; # M\u00E9lanome<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Topic\/cancer_recherche<\/a>> ; # Cancer--Recherche<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Topic\/resveratrol<\/a>> ; # Resv\u00E9ratrol<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Thing\/cellules_normales<\/a>> ; # Cellules normales<\/span>\n\u00A0\u00A0\u00A0\nschema:author<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Person\/nivelle_laetitia_1988<\/a>> ; # Laetitia Nivelle<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Organization\/universite_de_reims_champagne_ardenne<\/a>> ; # Universit\u00E9 de Reims Champagne-Ardenne.<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Person\/schini_kerth_valerie<\/a>> ; # Val\u00E9rie Schini-Kerth<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Person\/martiny_laurent<\/a>> ; # Laurent Martiny<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Person\/delmas_dominique_1972<\/a>> ; # Dominique Delmas<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Person\/aires_virginie_1978<\/a>> ; # Virginie Aires<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Person\/rossi_claire_1979_biologiste<\/a>> ; # biologiste). Claire Rossi<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Organization\/ecole_doctorale_sciences_technologies_sante_reims_marne<\/a>> ; # Ecole doctorale Sciences, technologies, sant\u00E9 (Reims, Marne).<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Person\/tarpin_michel_19_biologiste<\/a>> ; # biologiste). Michel Tarpin<\/span>\n\u00A0\u00A0\u00A0\nschema:datePublished<\/a> \"2017<\/span>\" ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"Resveratrol, a natural stilbene found in the grapevine, exhibits pleiotropic antitumor activities. This molecule has been shown to inhibit the cancerogenesis processes at different levels. Its impact in tumor growth, in vitro, is generally associate with a disruption in cell cycle and an apoptosis induction. Various resveratrol derivatives appear also efficient to modulate tumor growth. We have studied, during this work, biological activities of stilbenes produced by grapevine cell cutures. Our results show a decrease in melanoma human growth, in vitro, for bioproduced resveratrol oligomers as well as resveratrol itself. Our experiments underline distinct effects between resveratrol and its derivatives. Indeed, all compounds disrupt cell cycle, but resveratrol induces S-phase arrest while resveratrol oligomers failed to induce a clearly phase arrest. Moreover, only resveratrol oligomers only have the ability to counteract invasive and migratory properties of melanoma cells. Finally, experiments performed in normal human fibroblasts study show that resveratrol oligomers present a similar potential to reduce viability of cancer as well as normal cells contrary to resveratrol which is less efficient in normal cells. However the cytotoxicity of resveratrol and its derivatives is significantly reduced on normal cells.<\/span>\"@fr<\/a> ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"Le resv\u00E9ratrol, stilb\u00E8ne produit naturellement dans les grappes de raisin, poss\u00E8de un pouvoir anti-tumoral caract\u00E9ris\u00E9 par ses effets pl\u00E9\u00EFotropiques. La mol\u00E9cule s\'est ainsi montr\u00E9e capable d\'inhiber la canc\u00E9rogen\u00E8se en agissant \u00E0 de multiples niveaux. Son incidence sur la croissance tumorale in vitro est g\u00E9n\u00E9ralement associ\u00E9e \u00E0 une perturbation dans le cycle cellulaire et \u00E0 une induction d\'apoptose. De nombreuses mol\u00E9cules d\u00E9riv\u00E9es du resv\u00E9ratrol se sont montr\u00E9es \u00E9galement efficaces pour moduler la croissance tumorale. Nous avons entrepris au cours de ces travaux de th\u00E8se d\'\u00E9tudier les activit\u00E9s biologiques de stilb\u00E8nes issus d\'une production de culture cellulaire de vigne. Les r\u00E9sultats de cette \u00E9tude mettent en \u00E9vidence une r\u00E9duction de la croissance tumorale, dans un mod\u00E8le d\'\u00E9tude in vitro de m\u00E9lanome humain, pour le resv\u00E9ratrol et quatre oligom\u00E8res de resv\u00E9ratrol bioproduits. L\'\u00E9tude plus approfondie de trois oligom\u00E8res de resv\u00E9ratrol a permis de r\u00E9v\u00E9ler des diff\u00E9rences notables par rapport entre les effets du resv\u00E9ratrol et ses d\u00E9riv\u00E9s. En effet, bien que l\'inhibition de la viabilit\u00E9 cellulaire des lign\u00E9es canc\u00E9reuses s\'accompagne d\'une perturbation du cycle cellulaire pour le resv\u00E9ratrol et ses d\u00E9riv\u00E9s, elle se traduit diff\u00E9remment selon les compos\u00E9s. L\'action du resv\u00E9ratrol sur le cycle cellulaire conduit \u00E0 une nette augmentation des cellules en phase S, tandis que les oligom\u00E8res de resv\u00E9ratrol n\'induisent pas d\'accumulation cellulaire franche dans une phase du cycle. De plus les oligom\u00E8res de resv\u00E9ratrol pr\u00E9sentent des capacit\u00E9s anti-invasives et anti-migratoires qui ne sont pas retrouv\u00E9es chez le resv\u00E9ratrol. Enfin l\'\u00E9tude sur des fibroblastes normaux d\'adultes (FNA) souligne que les d\u00E9riv\u00E9s du resv\u00E9ratrol diminuent la viabilit\u00E9 de cellules normales et canc\u00E9reuses \u00E0 des concentrations similaires contrairement au resv\u00E9ratrol dont l\'action est nettement inf\u00E9rieure sur les cellules saines. Cependant le pouvoir cytotoxique du resv\u00E9ratrol et de ses d\u00E9riv\u00E9s reste beaucoup plus faible chez les cellules normales.<\/span>\"@fr<\/a> ;\u00A0\u00A0\u00A0\nschema:exampleOfWork<\/a> <http:\/\/worldcat.org\/entity\/work\/id\/4822737063<\/a>> ;\u00A0\u00A0\u00A0\nschema:genre<\/a> \"Th\u00E8ses et \u00E9crits acad\u00E9miques<\/span>\"@fr<\/a> ;\u00A0\u00A0\u00A0\nschema:inLanguage<\/a> \"fr<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Etude des propri\u00E9t\u00E9s anti-tumorales in vitro de stilb\u00E8nes issus de suspension cellulaire de vigne (Vitis labrusca)<\/span>\"@fr<\/a> ;\u00A0\u00A0\u00A0\nschema:productID<\/a> \"1028748766<\/span>\" ;\u00A0\u00A0\u00A0\nschema:url<\/a> <http:\/\/www.theses.fr\/2017REIMS014\/document<\/a>> ;\u00A0\u00A0\u00A0\nschema:url<\/a> <http:\/\/www.theses.fr\/2017REIMS014\/abes<\/a>> ;\u00A0\u00A0\u00A0\nwdrs:describedby<\/a> <http:\/\/www.worldcat.org\/title\/-\/oclc\/1028748766<\/a>> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n\n

Related Entities<\/h3>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Organization\/ecole_doctorale_sciences_technologies_sante_reims_marne<\/a>> # Ecole doctorale Sciences, technologies, sant\u00E9 (Reims, Marne).<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Organization<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Ecole doctorale Sciences, technologies, sant\u00E9 (Reims, Marne).<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Organization\/universite_de_reims_champagne_ardenne<\/a>> # Universit\u00E9 de Reims Champagne-Ardenne.<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Organization<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Universit\u00E9 de Reims Champagne-Ardenne.<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Person\/aires_virginie_1978<\/a>> # Virginie Aires<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:birthDate<\/a> \"1978<\/span>\" ;\u00A0\u00A0\u00A0\nschema:deathDate<\/a> \"\" ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Aires<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Virginie<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Virginie Aires<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Person\/delmas_dominique_1972<\/a>> # Dominique Delmas<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:birthDate<\/a> \"1972<\/span>\" ;\u00A0\u00A0\u00A0\nschema:deathDate<\/a> \"\" ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Delmas<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Dominique<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Dominique Delmas<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Person\/martiny_laurent<\/a>> # Laurent Martiny<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Martiny<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Laurent<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Laurent Martiny<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Person\/nivelle_laetitia_1988<\/a>> # Laetitia Nivelle<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:birthDate<\/a> \"1988<\/span>\" ;\u00A0\u00A0\u00A0\nschema:deathDate<\/a> \"\" ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Nivelle<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Laetitia<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Laetitia Nivelle<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Person\/rossi_claire_1979_biologiste<\/a>> # biologiste). Claire Rossi<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:birthDate<\/a> \"1979<\/span>\" ;\u00A0\u00A0\u00A0\nschema:deathDate<\/a> \";<\/span>\" ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Rossi<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Claire<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"biologiste). Claire Rossi<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Person\/schini_kerth_valerie<\/a>> # Val\u00E9rie Schini-Kerth<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Schini-Kerth<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Val\u00E9rie<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Val\u00E9rie Schini-Kerth<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Person\/tarpin_michel_19_biologiste<\/a>> # biologiste). Michel Tarpin<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:birthDate<\/a> \"19..<\/span>\" ;\u00A0\u00A0\u00A0\nschema:deathDate<\/a> \";<\/span>\" ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Tarpin<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Michel<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"biologiste). Michel Tarpin<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Thing\/cellules_normales<\/a>> # Cellules normales<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Cellules normales<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Thing\/croissance_tumorale<\/a>> # Croissance tumorale<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Croissance tumorale<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Thing\/oligomeres_de_reveratrol<\/a>> # Oligom\u00E8res de rev\u00E9ratrol<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Oligom\u00E8res de rev\u00E9ratrol<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Topic\/cancer_recherche<\/a>> # Cancer--Recherche<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Cancer--Recherche<\/span>\"@fr<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Topic\/melanome<\/a>> # M\u00E9lanome<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"M\u00E9lanome<\/span>\"@fr<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/4822737063#Topic\/resveratrol<\/a>> # Resv\u00E9ratrol<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Resv\u00E9ratrol<\/span>\"@fr<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/id.loc.gov\/vocabulary\/countries\/fr<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:Place<\/a> ;\u00A0\u00A0\u00A0\ndcterms:identifier<\/a> \"fr<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/www.theses.fr\/2017REIMS014\/document<\/a>>\u00A0\u00A0\u00A0\nrdfs:comment<\/a> \"Acc\u00E8s au texte int\u00E9gral<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/www.worldcat.org\/title\/-\/oclc\/1028748766<\/a>>\u00A0\u00A0\u00A0\u00A0a \ngenont:InformationResource<\/a>, genont:ContentTypeGenericResource<\/a> ;\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/www.worldcat.org\/oclc\/1028748766<\/a>> ; # Etude des propri\u00E9t\u00E9s anti-tumorales in vitro de stilb\u00E8nes issus de suspension cellulaire de vigne (Vitis labrusca)<\/span>\n\u00A0\u00A0\u00A0\nschema:dateModified<\/a> \"2020-10-12<\/span>\" ;\u00A0\u00A0\u00A0\nvoid:inDataset<\/a> <http:\/\/purl.oclc.org\/dataset\/WorldCat<\/a>> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n\n

Content-negotiable representations<\/p>\n