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The Evaluation of new antiarrhythmic drugs : proceedings of the Symposium on How to Evaluate a New Antiarrhythmic Drug: the Evaluation of New Antiarrhythmic Agents for the Treatment of Ventricular Arrhythmias, held at Philadelphia, Pennsylvania, October 8-9, 1980

Author: Joel Morganroth
Publisher: The Hague ; Boston : Martinus Nijhoff ; Hingham, MA : Distributed by Kluwer Boston, 1981.
Series: Developments in cardiovascular medicine, v. 11.
Edition/Format:   Print book : Conference publication : EnglishView all editions and formats
Summary:

Proceedings of the First Symposium on New Drugs and Devices, held in Philadelphia, PA, USA (1980)

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Genre/Form: Conference papers and proceedings
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Additional Physical Format: Online version:
Symposium on How to Evaluate a New Antiarrhythmic Drug : the Evaluation of New Antiarrhythmic Agents for the Treatment of Ventricular Arrhythmias (1980 : Philadelphia, Pa.).
Evaluation of new antiarrhythmic drugs.
The Hague ; Boston : Martinus Nijhoff ; Hingham, MA : Distributed by Kluwer Boston, 1981
(OCoLC)733025928
Material Type: Conference publication
Document Type: Book
All Authors / Contributors: Joel Morganroth
ISBN: 9024724740 9789024724741 9024723361 9789024723362 9789400982727 9400982720 9789400982703 9400982704
OCLC Number: 10532844
Description: xiv, 323 pages : illustrations ; 25 cm.
Contents: How to evaluate a new antiarrhythmic drug: The challenge of sudden cardiac death.- How to evaluate a new antiarrhythmic drug: The challenge of sudden cardiac death.- Pre-Clinical Evaluation of a New Antiarrhythmic Agent.- Relationships between effects on cardiac electrophysiology and antiarrhythmic efficacy.- What animal models should be used to define antiarrhythmic efficacy: acute dog models?.- Description of chronic canine myocardial infaction models suitable for the electropharmacologic evaluation of new antiarrhythmic drugs.- Non-canine animal models for evaluating antiarrhythmic efficacy General Group Discussion: Animal Models.- Defining the pharmacodynamics and pharmacokinetics of new antiarrhythmic drugs General Group Discussion: Pharmacology.- Chronic Studies in Patients with Non-Hemodynamically Significant Ventricular Arrhythmics.- How should Holter monitoring analysis be performed?.- Long-term ambulatory electrocardiographic recording in the determination of efficacy of new antiarrhythmic agents.- Evaluation of antiarrhythmic drugs. Should the Lown classification be used as a measure of efficacy?.- General Group Discussion: Holter Monitoring.- Study Designs: Chronic Patients.- New means of evaluating antiarrhythmic drugs.- Parallel or crossover designs in evaluation of antiarrhythmic therapy.- General Group Discussion: Study Designs: Chronic Patients.- Remarks: J. Richard Crout, Director, Bureau of Drugs Food and Drug Administration.- Acute Studies in Patients with Hemodynamically Significant Significant Ventricular Arrhythmias.- Acute drug testing as a part of a systematic approach to antiarrhythmic drug therapy.- What is the role of electrophysiology in drug testing? General Group Discussion: Electrophysiology.- What should the study design be to test new antiarrhythmic drugs in patients with acute myocardial infarction, digitalis toxicity and other acute problems General Group Discussion: Study Designs in Acute Patients.- Special Considerations.- What baseline electrophysiologic data should be obtained (plus discussion).- Assessment of the hemodynamic and inotropic effects of antiarrhythmic drugs (plus discussion).- Evaluation of drug treatment in supraventricular arrhythmias (plus discussion).- How should long-term safety of a new antiarrhythmic drug be defined (plus discussion).- How should one manage emergency drug requests and their data (puls discussion).- How does one evaluate and use outside U.S.A. data in the new drug application (plus discussion).
Series Title: Developments in cardiovascular medicine, v. 11.
Responsibility: edited by Joel Morganroth [and others].

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