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Exploring prokaryotic diversity in the genomic era

Author: Hugenholtz, Philip
Publisher: BioMed Central Ltd. 2002-01-29
Edition/Format:   Downloadable article : English
Publication:BioMed Central Ltd.
Summary:
Abstract Our understanding of prokaryote biology from study of pure cultures and genome sequencing has been limited by a pronounced sampling bias towards four bacterial phyla - Proteobacteria, Firmicutes, Actinobacteria and Bacteroidetes - out of 35 bacterial and 18 archaeal phylum-level lineages. This bias is beginning to be rectified by the use of phylogenetically directed isolation strategies and by directly  Read more...
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Genre/Form: Review
Material Type: Internet resource
Document Type: Internet Resource, Article
All Authors / Contributors: Hugenholtz, Philip
OCLC Number: 732700450
Language Note: English

Abstract:

Abstract Our understanding of prokaryote biology from study of pure cultures and genome sequencing has been limited by a pronounced sampling bias towards four bacterial phyla - Proteobacteria, Firmicutes, Actinobacteria and Bacteroidetes - out of 35 bacterial and 18 archaeal phylum-level lineages. This bias is beginning to be rectified by the use of phylogenetically directed isolation strategies and by directly accessing microbial genomes from environmental samples.

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