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Factor VIII : Hemophilia and Von Willebrand Disease.

Author: David Green
Publisher: San Diego : Elsevier Science & Technology, 2018.
Edition/Format:   eBook : Document : English
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Green, David.
Factor VIII : Hemophilia and Von Willebrand Disease.
San Diego : Elsevier Science & Technology, ©2018
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: David Green
ISBN: 9780128129555 0128129557
OCLC Number: 1041890508
Description: 1 online resource (302 pages)
Contents: Intro; Title page; Table of Contents; Copyright; Author Biography; Preface; Acknowledgments; Introduction; FVIII/VWF: The Janus of Hemostasis; Chapter 1: Historical Background of Blood Coagulation; Abstract; Factor VIII and Hemophilia A; Von Willebrand Factor and Von Willebrand Disease; Summary; Chapter 2: Hemostasis and FVIII; Abstract; Normal Hemostasis; Alternative Pathway; Hemostasis in the Absence of FVIII; Laboratory Assessment of Hemostasis; Summary; Chapter 3: FVIII Anatomy and Physiology; Abstract; Isolation and Structure; Relationship to the Von Willebrand Factor. Cell of Origin, Secretion, and ClearanceActivation and Inactivation; Summary; Chapter 4: FVIII Genetics; Abstract; The FVIII Gene; FVIII Mutations; Application of Genetic Analyses; Summary; Chapter 5: Congenital Deficiency of Factor VIII: Hemophilia A; Abstract; Historical Aspects; Epidemiology; Clinical Manifestations of Hemophilia; Diagnosis of Hemophilia; Summary; Chapter 6: FVIII Concentrates; Abstract; The First FVIII Concentrates; Recombinant Concentrates; Adverse Events With Concentrates; Improving Concentrates; Summary; Chapter 7: General Management of Hemophilia; Abstract. Management of Acute HemorrhagesPerioperative Management; Prophylaxis; Lifestyle Measures; Future Approaches; Summary; Chapter 8: Antibodies to FVIII; Abstract; Alloantibodies; Autoantibodies; Chapter 9: The Von Willebrand Factor; Abstract; The VWF Gene; The VWF Protein; Clearance of VWF; Functions of VWF; Summary; Chapter 10: Von Willebrand Disease: Classification and Diagnosis; Abstract; Epidemiology; Classification; Clinical and Laboratory Evaluation; Diagnosis; Summary; Chapter 11: Treatment of Von Willebrand Disease; Abstract; Desmopressin; VWF Concentrates; Adjunctive Therapies. Management of Bleeding by VWD TypeOther Management Issues; Summary; Chapter 12: Acquired Von Willebrand Syndrome; Abstract; Immunologically Mediated Loss of VWF; Cardiovascular Disease; Myeloproliferative Disorders; Glycogen Storage Disease; Miscellaneous Disorders; Summary; Chapter 13: Factor VIII and Thrombosis; Abstract; Venous Thrombosis; Arterial Thrombosis; Treatment of Thrombosis in Patients With FVIII Deficiency; Summary; Chapter 14: Von Willebrand Factor and Thrombosis; Abstract; Atherothrombosis; Venous Thrombosis; Atrial Fibrillation/Embolic Stroke; Modification of VWF; Summary. Chapter 15: Factor VIII/Von Willebrand Factor: The Janus of CoagulationAbstract; Origin and Clearance of the FVIII/VWF Complex; Participation in Hemostasis; Role in Bleeding Disorders; Role in Thrombotic Disorders; The FVIII/VWF Complex in the Treatment of Bleeding Disorders; Areas for Future Investigation; Summary; Index.

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