Forgiveness of genetic variation: Functional interactions among bone traits in the distal femoral epiphysis. (Book, 2008) [WorldCat.org]
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Forgiveness of genetic variation: Functional interactions among bone traits in the distal femoral epiphysis.
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Forgiveness of genetic variation: Functional interactions among bone traits in the distal femoral epiphysis.

Author: Whitney Alexandra Booker; Karl J Jepsen
Publisher: 2008.
Dissertation: M.S. Mount Sinai School of Medicine of New York University 2008
Edition/Format:   Thesis/dissertation : Document : Thesis/dissertation : eBook   Computer File : EnglishView all editions and formats
Publication:Masters Abstracts International, 46-05
Summary:
We examined femora from adult female AXB/BXA recombinant inbred (RI) mouse strains to identify epiphyseal traits that are functionally related and to determine how interactions among these traits contribute to organ-level functionality. The results of this study validated that variation in bone morphology is linked to variation in trabecular architecture and tissue quality. More than 1/3 of the 36 correlations  Read more...
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Details

Genre/Form: Academic theses
Dissertations, Academic
Material Type: Document, Thesis/dissertation, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Whitney Alexandra Booker; Karl J Jepsen
ISBN: 9780549546214 0549546219
OCLC Number: 873976030
Notes: Source: Masters Abstracts International, Volume: 46-05, page: 2582.
Adviser: Karl J. Jepsen.
Description: 1 online resource (36 pages)

Abstract:

We examined femora from adult female AXB/BXA recombinant inbred (RI) mouse strains to identify epiphyseal traits that are functionally related and to determine how interactions among these traits contribute to organ-level functionality. The results of this study validated that variation in bone morphology is linked to variation in trabecular architecture and tissue quality. More than 1/3 of the 36 correlations examined were significant, indicating that many bone traits covaried or were functionally related. Path analysis revealed novel interactions between traits defining epiphyseal volume, body weight, trabecular architecture and tissue quality. The causal relationship among these traits suggested a biological adaptation process, which allows for the forgiveness of genetic variation in physical bone traits, so that bone can be flexible in creating functional structures.

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