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Fragment-based drug discovery : a practical approach

Author: Edward Zartler; Michael Shapiro
Publisher: Chichester, U.K. : John Wiley & Sons, 2008.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
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Fragment-based drug discovery is a faster, cheaper, smarter way to do drug discovery. Emphasizing practical guidance, with procedures, case studies, practical tips, and contributions from industry,  Read more...

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Document Type: Book
All Authors / Contributors: Edward Zartler; Michael Shapiro
ISBN: 9780470058138 0470058137
OCLC Number: 233544904
Description: ix, 285 pages : illustrations ; 25 cm
Contents: Introduction to fragment-based drug discovery / Mike Cherry and Tim Mitchell --
Designing a fragment process to fit your needs / Edward R. Zartler and Michael J. Shapiro --
Assembling a fragment library / Mark Brewer [and others] --
Practical aspects of using NMR in fragment-based screening / Johan Schultz --
Application of protein-ligand NOE matching to the rapid evaluation of fragment binding poses / William J. Metzler [and others] --
Target-immobilized NMR screening : validation and extension to membrane proteins / Virginie Früh, Robert J. Heetebrij, and Gregg Siegal --
In situ fragment-based medicinal chemistry : screening by mass spectrometry / Sally-Ann Poulsen and Gary H. Kruppa --
Computational approaches to fragment and substructure discovery and evaluation / Eelke van der Horst and Adriaan P. IJzerman --
Virtual fragment scanning : current trends, applications and web-based tools / Bradley Feuston [and others] --
Capture methods for fragment-based lead discovery / Stig K. Hansen and Daniel A. Erlanson --
Identification of high affinity [beta]-secretase inhibitors using fragment-based lead generation / Jeffrey S. Albert and Philip D. Edwards.
Responsibility: editors, Edward R. Zartler, Michael J. Shapiro.

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"This is a useful book for readers already familiar with the basic aspects of drug design and discovery." (ChemMedChem, October 2009) "This book provides an excellent resource for those in Read more...

 
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