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Fundamentals of Receptor, Enzyme, and Transport Kinetics (1993).

Author: John C Matthews
Publisher: Boca Raton, FL : CRC Press, 2017.
Series: CRC Press Revivals
Edition/Format:   eBook : Document : English : First editionView all editions and formats
Summary:
"Fundamentals of Receptor, Enzyme, and Transport Kinetics is the first book to pull together the most important topics in receptor, enzyme, and transport kinetics into a concise, easy-to-use format. Numerous equations are included, and key equations are graphed. For each graphed equation, important features are carefully explained. The book is organized so that simple material is presented first, providing a firm  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: John C Matthews
ISBN: 9780203713433 0203713435 9781351364584 1351364588 9781351364577 135136457X 9781351364560 1351364561
OCLC Number: 1014382680
Description: 1 online resource : text file, PDF.
Contents: Cover; Title Page; Copyright Page; Preface; The Author; Acknowledgment; Table of Contents; Part I: Receptors; Chapter 1 Introduction to Receptors; I. Receptor-Ligand Complexes; II. Affinity, Intrinsic Activity, and Effect; III. Receptor Stimulation and Physiological Effect; IV. Fundamentals of Receptor-Ligand Interaction; V. Antagonists and Activators; Chapter 2 Simple Receptor-Ligand Interactions; I. Ligand Binding; II. RL Lifetimes and Reaction Rate Constants; III. Chemical Equilibrium; IV. Equilibrium and Affinity Constants; V. Receptor-Ligand Interaction Energies. VI. The Langmuir Binding IsothermVII. The Practical Meaning of Affinity; VIII. Fractional Receptor Occupancy; IX. Linear Transformations; A. Double-Reciprocal or Lineweaver-Burk Equation; B. The Rosenthal-Scatchard Equation; C. The Eadie-Hofstee Equation; D. The Woolf Equation; X. Weighting Errors; Chapter 3 Overview of Techniques for Direct Measurement of Receptor-Ligand Interactions; I. Receptor Preparations; II. Choosing Receptor Ligands and Radioisotopes; III. Quantification of Radioactivity; IV. Equilibrium and Dynamic Binding Measurements; V. Fast and Slow Receptor-Ligand Interactions. VI. General Considerations in Receptor Binding MethodsA. Relationship between Receptor and Ligand Concentrations; B. Nonspecific Binding; C. Affinity; D. Choice of Isotope for Radiolabeling; E. Weighting Errors Inherent in the Use of Radioisotopes; VII. Calorimetry; Chapter 4 Receptor-Ligand Interactions That Generate Proportional Physiological Effects; I. Relationship between Ligand Binding and Effect; II. The Value pL[sub(2)]; III. pH Equations and Receptor-Ligand Interactions; IV. Relative Intrinsic Activity. Chapter 5 Overview of Mechanisms for Coupling of Receptor-Agonist Interactions with Physiological EffectsI. Introduction; II. Ion Channel-Linked Signal Transduction; III. Cyclic Nucleotide-Linked Signal Transduction; A. Stimulatory Receptors; B. Inhibitory Receptors; IV. Phosphatidyl Inositol-Linked Signal Transduction; V. Steroid Receptors; Chapter 6 Overview of Techniques for Measuring Receptor-Agonist Interactions Through Their Physiological Effects; I. Introduction; II. Effects on Whole Animals; III. Isolated Organs and Tissues; IV. Tissue Slices, Cell Cultures, and Membrane Vesicles. V. Receptor-Effector Systems at the Molecular LevelChapter 7 Receptor-Ligand Interactions that are Disproportionate with Their Physiological Effects; I. Introduction; II. Spare Receptors; III. Homotropic Cooperativity and the Hill Equation; IV. Discrepancies in and Alternatives for the Hill Equation; V. Physiological Advantages of Homotropic Cooperativity; A. Hemoglobin; B. Calmodulin; VI. Heterotropic Cooperativity; VII. Receptor Desensitization; Chapter 8 Antagonism; I. Introduction; II. Types of Antagonism; A. Chemical Antagonism; B . Physical Antagonism; C. Functional Antagonism.
Series Title: CRC Press Revivals

Abstract:

"Fundamentals of Receptor, Enzyme, and Transport Kinetics is the first book to pull together the most important topics in receptor, enzyme, and transport kinetics into a concise, easy-to-use format. Numerous equations are included, and key equations are graphed. For each graphed equation, important features are carefully explained. The book is organized so that simple material is presented first, providing a firm foundation on which to cover the advanced topics which appear later. Terminology used throughout the book is consistent with that used in scientific literature, and concepts are explained using analogies from daily life. The book also features two important appendices that will be particularly useful learning tools. The first appendix outlines all of the key equations from the text and indicates their use. The second appendix is a set of sample calculation problems and their solutions. Fundamentals of Receptor, Enzyme, and Transport Kinetics is an excellent text/reference for pharmacologists, biological chemists, experimental biologists, neurochemists, neurotoxicologists, physiologists, and toxicologists. It is also suitable as a graduate-level text in pharmacology and medical pharmacology."--Provided by publisher.

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