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Fungal Pathogenesis : Principles and Clinical Applications

Author: Richard Calderone
Publisher: Boca Raton, FL : CRC Press, 2001.
Series: Mycology
Edition/Format:   eBook : Document : English : First editionView all editions and formats
Summary:
"Stresses molecular and biochemical studies of opportunistic and frank fungal pathogens!This book gives a comprehensive overview of human pathogenic fungi that offers a current and concise survey of virulence factors, host responses and recognition, treatment and diagnosis of infections, invasive enzymes, intracellular survival, morphogenesis, adaptation, and properties of major fungal pathogens that contribute to  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Richard Calderone
ISBN: 9781482270907 1482270900 9781466522183 1466522186
OCLC Number: 1027782695
Description: 1 online resource : text file, PDF
Contents: Cover; Half Title; Title Page; Copyright Page; Dedication; Contents; Preface; Introduction; Contributors; PART I. WHAT MAKES FUNGI VIRULENT?; 1 Host Recognition by Human Fungal Pathogens; I. INTRODUCTION; II. CARBOHYDRATE-PROTEIN (LECTINLIKE) BINDING SYSTEMS; A. Carbohydrate Adhesins; B. Adhesins Recognizing Host Carbohydrates; III. LIPID RECOGNITION; IV. PROTEIN·PROTEIN RECOGNITION; A. Adhesins Recognizing Serum Proteins; B. Adhesins Recognizing ECM Proteins; V . SUMMARY; ACKNOWLEDGMENTS; REFERENCES; 2 Genetic Basis of Pathogenicity in Cryptococcus neo formans; I. INTRODUCTION II. ROLE OF BIOLOGY IN C. NEOFORMANS PATHOGENESISIII. DEFINING VIRULENCE IN CRYPTOCOCCUS NEOFORMANS; IV. ROLE OF MORPHOLOGY IN PATHOGENICITY; A. Mating and Mating Type; B. Monokaryotic Fru iting; C . Switching; V. GENETIC VARIATION; VI. VIRULENCE FACTORS; A. Capsule; B. Melanin; C . Signal Transduction Homologs; D. Phospholipase; E. Mannitol; VII. ROLE OF THE HOST IMMUNE SYSTEM IN VIRULENCE; A. Race; B. Gender; C. Host Immune Status; D. Animal Models of Virulence; VIII. FUTURE RESEARCH; REFERENCES; 3 Secretory Proteins in Fungal Virulence; I. INTRODUCTION; II. PHOSPHOllPASES A. Phospholipases of Candida SpeciesB. Phospholipases of Cryptococcus Species; C. Phospholipases of Aspergillus Species; D. Role of Phospholipases in Fungal Virulence; E. Role of Fungal Extracellular Phosphollpases in Other Virulence Facilitating Functions; III. SECRETORY ASPARTIC PROTEINASES; A. Proteinases of Candida Species; B. Proteinases of Aspergillus Species; C. Role of Secretory Aspartic Proteinases in Fungal Virulence; IV. FUNGAL SECRETORY PROTEINS AS THERAPEUTIC AND DIAGNOSTIC TOOLS; A. Phospholipases; B. Secretory Aspartic Proteinases; V . CONCLUSION; ACKNOWLEDGMENTS; REFERENCES 4 Histoplasma capsulatum: Diary of an Intracellular SurvivorI. INTRODUCTION; II. RECOGNITION AND PHAGOCYTOSIS OF H. CAPSULATUM; III. STIMULATION OF THE RESPIRATORY BURST A ND PHAGOLYSOSOMAL (PL) FUSION; IV. STRATEGY FOR INTRACELLULAR SURVIVAL IN MACROPHAGES; V. MACROPHAGE ACTIVATION AND COUNTERSTRATEGIES; VI. DO NEUTROPHILS PLAYA ROLE?; VII. INTERACTION WITH DENDRITIC CELLS; VIII. CONCLUSIONS; ACKNOWLEDGMENT; REFERENCES; 5 Dimorphism in Human Pathogens; I. INTRODUCTION; II. WHAT IS DIMORPHISM? TERMINOLOGY AND STRUCTURES; III. ENVIRONMENTAL AND HOST-ADAPTED PATHOGENIC MORPHOLOGIES IV. WHY DO SOME FUNGI PRACTICE DIMORPHISM?A. Histoplasma capsulatum; B. Candida albicans; V. IMPORTANCE OF MORPHOGENESIS FOR VIRULENCE; A. Histoplasma capsulatum; B. Candida albicans; VI. REGULATION OF MORPHOGENESIS; A. Histoplasma capsulatum; B. Candida albicans; VII. MORPHOTYPE-SPECIFIC GENE EXPRESSION; A. Histoplasma capsulatum Yeast-Specific Gene Expression; B. Candida albicans Hypha-Specific Gene Expression; C. Blastomyces dermatitidis Yeast-Specific Gene Expression; VIII. SUMMARY; REFERENCES; 6 Signaling and the Biology of Human Fungal Pathogens; I. INTRODUCTION
Series Title: Mycology
Responsibility: Richard Calderone.

Abstract:

Offers a survey of virulence factors, host responses and recognition, treatment and diagnosis of infections, invasive enzymes, intracellular survival, morphogenesis, adaptation, and properties of  Read more...

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