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Fungal substances as modulators of NF-κB activation pathway
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Fungal substances as modulators of NF-κB activation pathway

Author: Roumyana D Petrova Affiliation: International Center for Cryptogamic Plants and Fungi, Institute of Evolution, University of Haifa, Mt. Carmel, Haifa, IsraelJamal Mahajna Affiliation: Migal-Galilee Technology Center, South Industrial Zone, Kiryat Shmona, IsraelAbraham Z Reznick Affiliation: Faculty of Medicine, Technion, Haifa, IsraelSolomon P Wasser Affiliation: International Center for Cryptogamic Plants and Fungi, Institute of Evolution, University of Haifa, Mt. Carmel, Haifa, IsraelCvetomir M Denchev Affiliation: Institute of Life Science and Natural Resources, Korea University, Seoul, KoreaAll authors
Edition/Format: Article Article : English
Publication:Molecular Biology Reports : An International Journal on Molecular and Cellular Biology, v34 n3 (200709): 145-154
Other Databases: WorldCatWorldCatWorldCat
Summary:
MCF7 breast cancer cell line, carrying a luciferase reporter gene under the control of nuclear factor kappa B (NF-κB)-responsive promoter, was established and used for the screening of fungal organic extracts for their ability to interfere with the NF-κB activation pathway. Twenty-eight crude fungal extracts, out of 242, were found to inhibit NF-κB reporter activity by more than 40%. Furthermore, positive extracts  Read more...
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Document Type: Article
All Authors / Contributors: Roumyana D Petrova Affiliation: International Center for Cryptogamic Plants and Fungi, Institute of Evolution, University of Haifa, Mt. Carmel, Haifa, Israel; Jamal Mahajna Affiliation: Migal-Galilee Technology Center, South Industrial Zone, Kiryat Shmona, Israel; Abraham Z Reznick Affiliation: Faculty of Medicine, Technion, Haifa, Israel; Solomon P Wasser Affiliation: International Center for Cryptogamic Plants and Fungi, Institute of Evolution, University of Haifa, Mt. Carmel, Haifa, Israel; Cvetomir M Denchev Affiliation: Institute of Life Science and Natural Resources, Korea University, Seoul, Korea; Eviatar Nevo Affiliation: International Center for Cryptogamic Plants and Fungi, Institute of Evolution, University of Haifa, Mt. Carmel, Haifa, Israel
ISSN:0301-4851
Language Note: English
Unique Identifier: 5660239967
Awards:

Abstract:

MCF7 breast cancer cell line, carrying a luciferase reporter gene under the control of nuclear factor kappa B (NF-κB)-responsive promoter, was established and used for the screening of fungal organic extracts for their ability to interfere with the NF-κB activation pathway. Twenty-eight crude fungal extracts, out of 242, were found to inhibit NF-κB reporter activity by more than 40%. Furthermore, positive extracts were used to evaluate their antiproliferative activity as well as their ability to influence the phosphorylation and degradation levels of IκBa. Fungal extracts prepared from Marasmius oreades and Cyathus striatus showed significant inhibitory effects on the NF-κB activation pathway. Taken together, our results support the notion of the presence of novel activities that might be utilized as cancer therapeutics.

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