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Genetic diversity in the transferrin receptor 1 (TfR1) among natural hosts of the North American arenaviruses Preview this item
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Genetic diversity in the transferrin receptor 1 (TfR1) among natural hosts of the North American arenaviruses

Author: Sheri B Ayers; Texas Tech University. Museum.
Publisher: Lubbock, TX : Museum of Texas Tech University, 2011.
Series: Occasional papers (Texas Tech University. Museum), no. 304.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
For some arenaviruses, cellular entry into a host species may involve the interaction of the host transferrin receptor 1 gene (TfR1) and the arenaviral glycoprotein. To examine this scenario, a 42 bp nucleotide region of the TfR1 gene, surrounding five conserved amino acid residues (208-212) and the apical domain, was sequenced in host species of North American arenaviruses. The goal was to determine if this region:  Read more...
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Document Type: Book
All Authors / Contributors: Sheri B Ayers; Texas Tech University. Museum.
OCLC Number: 768165047
Notes: Cover title.
Description: 15 pages : illustrations ; 28 cm.
Series Title: Occasional papers (Texas Tech University. Museum), no. 304.
Responsibility: Sheri B. Ayers and Robert D. Bradley.

Abstract:

For some arenaviruses, cellular entry into a host species may involve the interaction of the host transferrin receptor 1 gene (TfR1) and the arenaviral glycoprotein. To examine this scenario, a 42 bp nucleotide region of the TfR1 gene, surrounding five conserved amino acid residues (208-212) and the apical domain, was sequenced in host species of North American arenaviruses. The goal was to determine if this region: 1) differed between infected and uninfected individuals of the same host; 2) was polymorphic in a species known to host three genetically divergent strains of a single arenavirus; 3) varied in different rodent species infected with the same arenavirus; and 4) varied between host species and non-host species. Phylogenetic and genetic distance analyses revealed that nucleotides and amino acids were conserved regardless of the host species, arenavirus, or whether a host was infected or uninfected. Results indicated that the TfR1 may not be involved in cellular transportation of North American arenaviruses.

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