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Genetic toxicology and cancer risk assessment

Author: Wai Nang Choy
Publisher: New York : Marcel Dekker, ©2001.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This work reviews the roles of genetic toxicology in cancer risk assessment conducted by regulatory agencies worldwide - discussing hazard identification, dose-response relationships, exposure assessment and practices of risk characterization.
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Genre/Form: Electronic books
Electronic book
Additional Physical Format: Print version:
Genetic toxicology and cancer risk assessment.
New York : Marcel Dekker, ©2001
(DLC) 2001042183
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Wai Nang Choy
ISBN: 0585408106 9780585408101 0824745221 9780824745226 0203904230 9780203904237 0824702948 9780824702946
OCLC Number: 50321547
Description: 1 online resource (xiii, 390 pages) : illustrations
Contents: Human cancer genetics --
Genetic toxicity for predicting carcinogenicity --
Genotoxic and nongenotoxic mechanisms of carcinogenesis --
Structure-activity relationship (SAR) and its role in cancer risk assessment --
Regulatory genetic toxicology tests --
Complementary genetic toxicology assays --
The mouse lymphoma assay (MLA) using the microwell method --
The in vivo micronucleus assay --
ICH guidances on genotoxicity and carcinogenicity: scientific background and regulatory practice --
New OECD genetic toxicology guidelines and interpretation of results --
Dose-response relationships in chemical carcinogenesis and cancer risk assessment --
Molecular epidemiology and biomarkers --
Quantitative cancer risk assessment of nongenotoxic carcinogens --
Risk assessment of genotoxic carcinogens --
Biologically based cancer risk assessment models.
Responsibility: edited by Wai Nang Choy.
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Abstract:

Presenting regulatory cancer risk assessment models, this book includes a biologically based model for two-hit carcinogenesis and cell proliferation. It reviews the various roles of genetic  Read more...

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"engaging and informative. a useful contribution to the field of genetic toxicology. "-Doody "well-detailed. a great reference material. "-Australian Journal of Medical Science "offers the reader an Read more...

 
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