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Genetics : from genes to genomes

Author: Leland Hartwell
Publisher: Boston : McGraw-Hill, ©2000.
Edition/Format:   Print book : EnglishView all editions and formats
CD-ROM contains: Animations of basic genetic processes -- Interactive exercises and simulations -- Self-tests -- Glossary definitions.

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Document Type: Book
All Authors / Contributors: Leland Hartwell
ISBN: 0075409232 9780075409236 007235822X 9780072358223
OCLC Number: 41096081
Notes: Includes index.
Description: xxiii, 813 pages : illustrations (some color) ; 28 cm
Details: System requirements: Macintosh or Windows.
Contents: Part 1 Basic principles: how to traits are transmitted - Mendel's breakthrough - patterns, particles, and principles of heredity; extensions to Mendel - complexities in relating genotype of phenotype; the chromosome theory of inheritance; linkage, recombination, and the mapping of genes on chromosomes. Part 2 What genes are and what they do: DNA - the molecule of heredity carries, replicates, and recombines information; anatomy and function of a gene - dissection through mutation; gene expression - the flow of genetic information from DNA via RNAS to protein. Part 3 Using genetic engineering to unravel the information in genomes: DNA at high resolution - use of DNA cloning, PCR, and hybridization as the tools of genetic analysis; the direct detection of genotype; the mapping and analysis of genomes. Part 4 How genes travel: the eukaryotic chromosome - an organelle for packaging and managing DNA; chromosomal rearrangements and changes in chromosome number reshape eukaryotic genomes; the prokaryotic chromosome -genetic analysis in bacteria; the chromosomes of organelles outside the cell; nucleus exhibit; non Mendelian patterns of inheritance. Part 5 How genes are regulated: gene regulation in prokaryotes; gene regulation in eukaryotes; cell-cycle regulation and the genetics of cancer. Part 6 Gene regulation and development: portraits of model eukaryotic organisms - introduction - the use of genetics in the study of development; saccharomyces cerivisia - genetic portrait of yeast; arabidopsis thaliana - genetic portrait of yeast; caenorhabditis elegans - genetic portrait of a simple metazoan; drosophila melanogaster - genetic portrait of the fruit fly; mus musculus -genetic portrait of the house mouse. Part 7 How genes change: the genetic analysis of populations and how they evolved; evolution at the molecular level.
Responsibility: Leland Hartwell [and others].


This text looks at four major themes related to genetics: the central importance of the genome; the application of genetics to the human; the growing appreciation for the relationships among  Read more...


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