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Growth regulation and carcinogenesis. Volume I

Author: Walter R Paukovits
Publisher: Boca Raton : CRC Press, Taylor & Francis Group, [2018]
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Growth Regulation and Carcinogenesis discusses topics such as growth factors, including stimulators and inhibitors of proliferation; networks in proliferation regulation; differentiation-inducing factors; origins of neoplasia and their relationship to growth control; genetic alterations in cellular regulatory machinery; extrachromosomal phenomena; non-genotoxic carcinogens; immortalization and transformation of  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Paukovits, Walter R.
Growth Regulation and Carcinogenesis : Volume I.
Milton : CRC Press, ©2018
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Walter R Paukovits
ISBN: 9781351080774 1351080776 9781351072328 1351072323
OCLC Number: 1020696872
Description: 1 online resource (327 pages)
Contents: Cover --
Title Page --
Copyright Page --
TABLE OF CONTENTS --
SECTION 1: GENERAL CONCEPTS --
Chapter 1: The Classical Concepts of the Origin and Development of Malignant Tumors --
Chapter 2: Control of Gene Expression during Cell Cycle and Growth of Mammalian Cells --
Chapter 3: Transit, Exit, and Arrest Models for Control of the Mammalian Cell Cycle --
Chapter 4: Cancer-A Disease of Tissue Neogenesis? --
Chapter 5: Neoplasia and the Wound Response: The Lesson Learned from the Multistage Approach of Skin Carcinogenesis --
SECTION 2: CELL TRANSFORMATION --
Chapter 1: The Role of Polypeptide Growth Factors in Phenotypic Transformation of Normal Cells --
Chapter 2: Density-Development Control of Cell Proliferation: Molecular Mechanisms Involved in Contact-Inhibition --
Chapter 3: Cancer as a Mutation-Driven Evolutionary Process --
Chapter 4: Mutation-Driven Evolution of Rev-T --
Chapter 5: Expression of ras, myc, and erb-A Proto-Oncogenes in Preneoplastic Rat Liver during Chemical Carcinogenesis --
Chapter 6: Oncogene Expression in Preneoplastic and Neoplastic Lesions --
Chapter 7: Timing of Proto-Oncogene Replication and its Relationship to Transformation Sensitivity to Chemical Carcinogens --
Chapter 8: The Roles of Cell Proliferation and Gene Replication in Neoplastic Transformation --
Chapter 9: Oncogene Amplification: myc and neu Oncoproteins --
Chapter 10: Structure, Expression, and Oncogenic Activity of the myc Gene Family --
Chapter 11: The myc Family of Nuclear Oncoproteins: Structure, Biochemistry, and Activities --
SECTION 3: FROM FACTOR DEPENDENCE TO FACTOR INDEPENDENCE --
Chapter 1: Critical Variables for the Oncogene-Induced Immortalization of Fischer Rat Embryo Cells --
Chapter 2: Biological Aspects of the Process --
Chapter 3: Immortalization of Cultured Mammalian Cells: A brief Review of the Recent Literature. Chapter 4: Transfer of an Extrachromosomal, Cytoplasmic Mouse DNA Leads to Immortalization of Human Lymphocytes without Induction of the Tumorigenic Phenotype --
Chapter 5: Growth Regulation in Normal and Malignant Melanocytes --
Chapter 6: Paracrine Interactions Govern the Progression of Lympho-hemopoietic Malignancies: Evidence from Long-Term Marrow Cultures --
Chapter 7: ras Oncogene Mediates Paracrine Interactions between Leukemic Progenitor Cells and Stromal Elements --
Chapter 8: Role of Oncogenes in the Abrogation of Growth Factor Requirements of Hemopoietic Cells --
Index.
Responsibility: editor Walter R. Paukovits.

Abstract:

Growth Regulation and Carcinogenesis discusses topics such as growth factors, including stimulators and inhibitors of proliferation; networks in proliferation regulation; differentiation-inducing factors; origins of neoplasia and their relationship to growth control; genetic alterations in cellular regulatory machinery; extrachromosomal phenomena; non-genotoxic carcinogens; immortalization and transformation of cells; and the role of cell production, cell function, and cell elimination in physiological growth control.

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