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Handbook of neuroemergency clinical trials

Author: Brett Evan Skolnick; Wayne M Alves
Publisher: London : Elsevier Academic Press, [2018]
Edition/Format:   eBook : Document : English : 2nd edView all editions and formats
Summary:
Handbook of Neuroemergency Clinical Trials, Second Edition, focuses on the practice of clinical trials in acute neuroscience populations, or what have been called neuroemergencies. Neuroemergencies are complex, life-threatening diseases and disorders, often with devastating consequences, including death or disability. The overall costs are staggering in terms of annual incidence and costs associated with treatment  Read more...
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Genre/Form: Electronic books
Handbooks and manuals
Electronic book
Handbooks, manuals, etc
Additional Physical Format: Print version:
(OCoLC)982435108
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Brett Evan Skolnick; Wayne M Alves
ISBN: 9780128041017 0128041013 9780128040645 0128040645
OCLC Number: 1007310314
Description: 1 online resource
Contents: Acute ischemic stroke / Bruce C.V. Campbell, Christopher F. Bladin, Geoffrey A. Donnan and Stephen M. Davis --
Subarachnoid hemorrhage / Robert Loch McDonald --
Clinical trials in spontaneous intracerebral hemorrhage / Fred Rincon and Stephan A. Mayer --
Imaging biomarkers in stroke trials / Hans Bakken and Max Wintermark --
Traumatic brain injury / Shamik Chakraborty, Brett E. Skolnick, Wayne M. Alves, Lawrence F. Marshall and Raj K. Narayan --
Improving approaches to evaluate efficacy and safety of drugs for tarumatic brain injury / Andrew I. R. Maas and David K. Menon --
Brain imaging in traumatic brain injury / Timothy I. Alves --
The use of blood-based biomarkers to improve the design of clinical trials of traumatic brain injury / Olena Y. Glushakova, Alexander V. Glushakov, Rebekah Mannix, Emmy R. Miller, Alex B. Valdka and Ronald L. Hayes --
Biostatistical issues in TBI clinical trials / Sharon D. Yeatts, Yuko Y. Palesch and Nancy Temkin --
Acute seizures and status epilepticus / Susan T. Herman --
Neuroemergencies in critical care patients / Jared A. Greenberg and Thomas P. Bleck --
Neuroemergency clinical trials / Stephen D. Silberstein and Thomas Berk --
Acute visual deficits / Clotilde Hainline, Alexandra Lloyd-Smith, Janet C. Rucker, Madhura A. Tamhankar and Laura J. Balcer --
Implications for new trials in acute ischemic stroke in the new era of endovascular therapy / Charlotte Zerna, Jessalyn K. Holodinsky, Mayank Goyal and Michael D. Hill --
The role of a project medical officer in acute neuroemergency clinical studies / Howard Levy --
Regulatory considerations / Steven B. Johnson --
Military perspectives on brain injuries / Geoffrey Ling, Nicole Draghic, Jamie Grimes and James Ecklund.
Responsibility: edited by Brett E. Skolnick, Wayne M. Alves.

Abstract:

Handbook of Neuroemergency Clinical Trials, Second Edition, focuses on the practice of clinical trials in acute neuroscience populations, or what have been called neuroemergencies. Neuroemergencies are complex, life-threatening diseases and disorders, often with devastating consequences, including death or disability. The overall costs are staggering in terms of annual incidence and costs associated with treatment and survival, yet despite their significance as public health issues, there are few drugs and devices available for definitive treatment. The book focuses on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. This volume provides neurologists, neuroscientists, and drug developers with a more complete understanding of the scientific and medical issues of relevance in designing and initiating clinical development plans for novel drugs intended for acute neuroscience populations. The editors provide the best understanding of the pitfalls associated with acute CNS drug development and the best information on how to approach and solve issues that have plagued drug development.

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