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Hepatitis Prevention and Treatment

Author: Joseph M Colacino; Beverly A Heinz
Publisher: Basel : Birkhäuser Basel : Imprint : Birkhäuser, 2004.
Series: Milestones in drug therapy.
Edition/Format:   eBook : Bibliographic data : EnglishView all editions and formats
Summary:
Chronic viral hepatitis has emerged as one of the most common causes of disease and death worldwide. Because of their unique modes of replication and intimate association with the host immune system, hepatitis B virus (HBV) and hepatitis C virus (HCV) pose challenging problems to scientists in basic and applied research as well as to clinicians engaged in disease management. Although approved antiviral therapy is  Read more...
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Details

Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Material Type: Bibliographic data, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Joseph M Colacino; Beverly A Heinz
ISBN: 9783034879033 3034879032 9783034896177 3034896174
OCLC Number: 840290266
Description: 1 online resource (XI, 246 pages).
Contents: Gururaj Kalkeri and Ann D. Kwong: History of viral hepatitis --
Lawrence M. Blatt and Myron Tong: Epidemiology of chronic hepatitis viruses: HBV and HCV --
Guangxiang (George) Luo: Molecular virology of hepatitis C virus --
Lynn D. Condreay and Sarah A. Harris: Molecular biology of hepatitis B virus --
Eleanor J. Barnes, Nasser Semmo and Paul Klenerman: Viral immunology --
HCV --
Tomasz I. Michalak: Immunology of HBV --
Anouk Dev, Keyur Patel and John G. McHutchison: Current standard of care in HCV --
Nathaniel A. Brown and Richard E. Boehme: Current treatment of patients with chronic hepatitis B virus infection --
Craig S. Gibbs: Viral response to therapy: viral dynamics --
Raymund R. Razonable and James M. McGill: Investigational drugs in clinical development for the treatment of chronic viral hepatits --
Tim Shaw and Stephen Locarnini: Problems inherent to antiviral therapy.
Series Title: Milestones in drug therapy.
Responsibility: edited by Joseph M. Colacino, Beverly A. Heinz.

Abstract:

Chronic viral hepatitis has emerged as one of the most common causes of disease and death worldwide. Because of their unique modes of replication and intimate association with the host immune system, hepatitis B virus (HBV) and hepatitis C virus (HCV) pose challenging problems to scientists in basic and applied research as well as to clinicians engaged in disease management. Although approved antiviral therapy is available for chronic HBV, the emergence of viral resistance provides a rationale for the development of novel chemotherapeutic agents. The lack of a robust cell culture system for HCV replication and a readily accessible small-animal model of HCV infection have hampered the development of antiviral agents for HCV. Neverthe-less, new antiviral agents targeting HCV are now in preclinical and clinical development. This monograph, providing an up-to-date overview of the field of Hepatitis Prevention and Treatment, includes contributions from internationally recognized experts in the field of viral hepatitis, and covers the current state of knowledge and practice regarding the molecular biology, immunology, biochemistry, pharmacology and clinical aspects of chronic HBV and HCV infection. The volume includes salient topics such as: the history and epidemiology of HBV and HCV; recent insights into the molecular mechanisms of viral replication; the host immune response to infection and a discussion of the use (HBV) or potential development (HCV) of vaccines; the current standard of care for chronically-infected patients; and emerging therapies and issues associated with current antiviral treatments. The latest information to researchers and clinicians actively engaged in viral hepatitis research is provided, but also sufficient background and discussion of the literature to benefit the newcomer to the field.

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