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Hepatocellular Carcinoma : Translational Precision Medicine Approaches

Author: Yujin Hoshida
Publisher: Cham : Humana Press, 2019.
Series: Molecular and translational medicine.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Hoshida, Yujin
Hepatocellular Carcinoma : Translational Precision Medicine Approaches
Cham : Humana Press,c2019
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Yujin Hoshida
ISBN: 9783030215408 3030215407
OCLC Number: 1111951352
Notes: Description based upon print version of record.
Background
Includes index.
Description: 1 online resource (365 p.).
Contents: Intro; Preface; Acknowledgments; Contents; Contributors; Part I: Clinical Demographics and Management; Chapter 1: Risk Factors of Hepatocellular Carcinoma for Precision Personalized Care; Introduction; Overview of HCC Prevention Strategies; Regular HCC Screening; Clinical Scores to Predict HCC Risk; Molecular Biomarkers to Predict HCC Risk; HCC Detection Modalities and Biomarkers for Regular HCC Screening; HCC Biomarker Development; Individual Risk-Based Tailored HCC Screening; Conclusions; References; Chapter 2: Hepatocellular Carcinoma Surveillance and Staging; HCC Surveillance Benefits of HCC SurveillancePatients with Chronic HBV Infection; Patients with Cirrhosis; Harms of HCC Surveillance; Surveillance Tests; Radiographic Surveillance Tests; Serologic Surveillance Tests; Surveillance Interval; Surveillance Utilization; HCC Surveillance Cost-Effectiveness; Staging; Barcelona Cancer Liver Cancer (BCLC); Hong Kong Liver Cancer (HKLC); Additional HCC Staging Systems; Conclusion; References; Chapter 3: Changing Epidemiology of Hepatocellular Carcinoma and Role of Surveillance; Introduction; HCC Incidence and Mortality Trends; Knowledge Gaps in HCC Surveillance Significance of Mathematical Modeling for Surveillance of HCCCost-Effectiveness of HCC Surveillance by Etiology; Hepatitis C Patients After Viral Cure; Nonalcoholic Fatty Liver Disease; Alcoholic Liver Disease; Heavy Alcohol Consumption with HBV/HCV; Conclusions; References; Part II: Diagnosis and Prognostication; Chapter 4: Radiological Diagnosis and Characterization of HCC; Introduction; Imaging Modalities; Ultrasound and Contrast-Enhanced Ultrasound; Contrast-Enhanced CT; MRI; MRI with ECCM; MRI with Liver-Specific Agents; Positron Emission Tomography-CT and MRI; Imaging Characteristics Diagnostic Imaging FeaturesAncillary Imaging Features; Staging; Quantitative Imaging in HCC; CT and MR Perfusion; Dual Energy CT; Diffusion-Weighted Imaging; Radiomics Quantification; Conclusion; References; Chapter 5: Analysis of Hepatocellular Carcinoma Tissue for Biomarker Discovery; Introduction; Treatment Options; Current Detection Methods; Glycosylation and Biomarkers of Hepatocellular Carcinoma; Broad Tissue Analysis in Hepatocellular Carcinoma; HCC Tissue Proteomics; HCC Glycomics; Future Directions and Conclusions; References Chapter 6: Molecular Subtypes and Genomic Signatures of Hepatocellular Carcinoma for Prognostication and Therapeutic Decision-MakingIntroduction; Clinical Staging of Hepatocellular Carcinoma; Molecular Profiling of Hepatocellular Carcinoma; Prognostic Subtypes of Hepatocellular Carcinoma Redefined by Supervised Approaches; Prognostic Subtypes of Hepatocellular Carcinoma Uncovered by Unsupervised or Semi-supervised Approaches; Nontumor Genomic Signatures; Conclusion and Perspective; References; Chapter 7: Liquid Biopsy in Hepatocellular Carcinoma; Introduction; Circulating Tumor Cells
Series Title: Molecular and translational medicine.
Responsibility: Yujin Hoshida, editor.

Abstract:

This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC. --

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