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Histopathology of Preclinical Toxicity Studies : Interpretation and Relevance in Drug Safety Evaluation.

Author: Peter Greaves
Publisher: Amsterdam : Elsevier Science, 2014.
Edition/Format:   eBook : Document : English : 4th edView all editions and formats
Summary:
The new 4<SUP>th</SUP> edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Greaves, Peter.
Histopathology of Preclinical Toxicity Studies : Interpretation and Relevance in Drug Safety Evaluation.
Amsterdam : Elsevier Science, ©2014
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Peter Greaves
ISBN: 9780444538611 0444538615
OCLC Number: 1054363380
Notes: Atrophy, hypoplasia, aplasia, lymphocyte depletion, unstimulated pattern.
Description: 1 online resource (893 pages)
Contents: Front Cover; Histopathology of Preclinical Toxicity Studies; Copyright Page; Contents; 1. Introduction; Pathology and the safety assessment of new medicines; Veterinary medicines; Toxicological screening; Carcinogenesis assessment; Comparative pathology; Techniques in pathology; Reporting of pathology findings; The following chapters; References; 2. Integumentary System; Skin and Subcutaneous Tissue; Non-neoplastic changes; Spontaneous inflammation and necrosis; Skin inflammation induced by topical administration; Inflammation and ulceration induced by systemic drug administration. Skin --
changes in pigmentation, hyperpigmentation and hypopigmentationEpidermal atrophy; Alopecia; Increased hair growth; Changes in sebaceous glands; Epidermal hyperplasia; Induced subcutaneous inflammation; Granuloma and granulomatous inflammation; Adipose tissue inflammation, fat necrosis and steatitis; Other changes in adipose tissue; Extramedullary hematopoiesis; Elastosis; Amyloid; Mineralization; Neoplasms of epidermal origin; Classification and diagnosis of skin tumors; Squamous papilloma; Sebaceous adenoma; Tumors showing hair follicle differentiation; Carcinoma. Neoplasms of the melanogenic systemNevi (benign melanoma); Malignant melanoma; Subcutaneous (soft tissue or mesenchymal) neoplasms; Induced subcutaneous soft tissue neoplasms: injected and implanted substances; Induced subcutaneous soft tissue neoplasms: drugs administered systemically; Classification; Histogenesis; Fibroma; Fibrosarcoma; Pleomorphic fibrosarcoma, pleomorphic sarcoma, malignant fibrohistiocytoma; Malignant histiocytoma, histiocytic sarcoma; Canine cutaneous histiocytoma; Mast cell tumor, mastocytoma; Lipoma; Hibernoma (brown fat tumor); Liposarcoma; Rhabdomyosarcoma. LeiomyomaLeiomyosarcoma; Proliferative vascular changes; Congestion; Angiectasis; Angiomatous Hyperplasia; Hemangioma (angioma, hemangioendothelioma, hemangiopericytoma); Hemangiosarcoma (angiosarcoma); Miscellaneous soft tissue neoplasms; References; 3. Mammary Gland; Endocrinology; Anatomy; Cytochemistry and immunocytochemistry; Non-neoplastic changes; Inflammation; Atrophy; Mammary gland enlargement; Cysts, cystic change, cystic degeneration, milk cysts, galactocele, duct ectasia; Hyperplasia; Duct hyperplasia; Lobular hyperplasia; Mammary neoplasia; Classification; Fibroadenoma; Adenoma. FibromaIntraduct papilloma; Carcinoma; Mammary carcinoma --
rat; Mammary carcinoma --
mouse; Mammary carcinoma --
hamster; Mammary carcinoma --
dog; Mammary carcinoma --
primates; Factors affecting prevalence of mammary neoplasms in experimental studies; Mammary tumors and safety assessment; References; 4. Hemopoietic and Lymphatic Systems; Blood and Bone Marrow; Humans; Laboratory animals; Red blood cell values; Platelet values; White blood cell and differential counts; Bone marrow; Lymphoid System; Immunotoxicology; Immunocytochemistry of lymphoreticular cells; Lymph Nodes.

Abstract:

The new 4<SUP>th</SUP> edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essential.

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