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Human prion diseases

Author: Maurizio Pocchiari; Jean C Manson
Publisher: Amsterdam, Netherlands : Elsevier, [2018] ©2018
Series: Handbook of clinical neurology, v. 153.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Human prion diseases.
Amsterdam, Netherlands : Elsevier, [2018]
(OCoLC)1007056296
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Maurizio Pocchiari; Jean C Manson
ISBN: 9780444639530 0444639535
OCLC Number: 1039718513
Description: 1 online resource (xiii, 498 pages) : illustrations (some color).
Contents: Section I: Pathophysiology of prions. The cellular and pathological prion protein --
Cell biology of prion infection --
Experimental models of human prion diseases and prion strains --
The role of the immune system in prion infection --
Section II: Animal prion diseases (clinical, epidemiology, neuropathological, biochemical, biomarker, and genotypes). Typical and atypical scrapie --
Typical and atypical BSE --
Chronic Wasting Disease --
Section III: Human prion diseases (clinical, epidemiology, neuropathological, biochemical, biomarker, and genotypes). Sporadic Creutzfeldt-Jakob Disease --
Variably protease-sensitive prionopathy --
Variant Creutzfeldt-Jakob Disease --
Iatrogenic Creutzfeldt-Jakob Disease --
Genetic Creutzfeldt-Jakob Disease --
Gerstmann-Sträussler-Scheinker disease --
Sporadic and fatal Familial Insomnia --
Section IV: Prion-like mechanisms in other neurodegenerative diseases. Prion-like mechanisms in Alzheimer --
Prion-like mechanisms in Parkinson --
Prion-like mechanisms in ALS --
Section V: Diagnosis and treatment. Prion protein amplification techniques --
Differential diagnosis with other rapid progressive dementias --
Symptomatic treatment, care and support of CJD patients --
Identifying therapeutic targets and treatment in model systems --
Vaccination strategies --
Clinical trials --
Section VI: Public health issues. Animal diseases and the zoonotic potential --
Safety of blood, blood derivatives and plasma-derived products --
Safety in clinical practice --
Concluding thoughts.
Series Title: Handbook of clinical neurology, v. 153.
Responsibility: edited by Maurizio Pocchiari, Jean Manson.

Abstract:

Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems"--Publisher's description.

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